Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rear detachment, and motility.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3875829 | PMC |
| http://dx.doi.org/10.1016/j.devcel.2013.09.013 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
WRAMPing up calcium in migrating cells by localized ER transport.
Dev Cell
September 2013
Departments of Pediatrics and Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA; Microbiology Doctoral Training Program, Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, WI 53706, USA.
Morphological plasticity and front-rear polarity are essential for directed cell migration. In this issue of Developmental Cell, Witze et al. (2013) demonstrate that Wnt5a-mediated signaling induces localization of the cortical endoplasmic reticulum to the trailing edge of melanoma cells and mediates calcium flux, rear detachment, and motility.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!