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ProBDNF as a Myokine in Skeletal Muscle Injury: Role in Inflammation and Potential for Therapeutic Modulation of p75.
Int J Mol Sci
January 2025
Division of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion, SD 57069, USA.
Brain-derived neurotropic factor (BDNF) is expressed by skeletal muscle as a myokine. Our previous work showed that the active precursor, proBDNF, is the predominant form of BDNF expressed in skeletal muscle, and that following skeletal muscle injury, proBDNF levels are significantly increased. However, the function of the muscle-derived proBDNF in injury-induced inflammation has yet to be fully understood.
View Article and Find Full Text PDFKnowledge, perceptions and healthcare practices of communities for management of snakebites in Kamuli District, Eastern Uganda.
Trans R Soc Trop Med Hyg
January 2025
Department of Community health and Behavioural Sciences, Makerere University School of Public Health, Kampala, Uganda.
Background: Snakebite is one of the neglected tropical diseases in Uganda affecting rural areas, especially during the rainy season. Households mainly rely on traditional remedies for management, which are not always effective, leading to disability and sometimes death. We explored the knowledge, perceptions and healthcare practices related to snakebites in Kamuli District.
View Article and Find Full Text PDFComparison of the effects of high tibial osteotomy with and without a tourniquet.
BMC Surg
December 2024
Department of Orthopaedics, The Second Affiliated Hospital of Anhui Medical University, Hefei, 230601, China.
Background: Tourniquets are routinely employed to achieve hemostasis in modern limb surgeries. Nevertheless, the precise role and benefits of tourniquets in high tibial osteotomy (HTO) surgeries remain understudied. The aim of this study was to assess the application of tourniquets in high-tibial osteotomy procedures.
View Article and Find Full Text PDFDoes Tourniquet Use Impact Early Patient Outcomes in Total Knee Arthroplasty?
Cureus
November 2024
Trauma and Orthopaedics, Calderdale and Huddersfield NHS Foundation Trust, Huddersfield, GBR.
Introduction Tourniquets are commonly used when performing total knee arthroplasty (TKA) to reduce intra-operative blood loss, improve surgical field visibility, and potentially improve cement penetration during prosthesis implantation. However, they may be associated with increased thigh pain, postoperative opiate use, and longer lengths of hospital stay. Methods Retrospectively collected data was obtained from our institution's electronic patient records and database.
View Article and Find Full Text PDFWide Awake Surgery Is Safe and Feasible in Pediatric Orthopaedic Surgery.
J Pediatr Orthop
December 2024
Connecticut Children's Medical Center, Hartford, School of Medicine, University of Connecticut, Farmington.
Objective: Wide awake local anesthesia no tourniquet (WALANT) techniques are increasingly utilized for hand surgeries in adults, given the clinical benefits to patients, reduced environmental waste during surgery, and lower costs to the health care system. This technique is not widely employed for pediatric hand surgeries given concerns for parental and patient anxiety, noncompliance during surgery, and tolerance of administration of local anesthesia. Select patients undergoing amenable procedures can potentially benefit from this method and enjoy the lower morbidities and costs that adult patients enjoy.
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