Leaves, bark and woody part of Ficus carica L. cultivar Dottato collected in different months were examined to assess their chemical composition, antioxidant activity and phototoxicity on C32 human melanoma cells after UVA irradiation. The phytochemical investigation revealed different composition in the coumarin, fatty acid, polyphenol and flavonoid content. The second harvest of leaves and the first harvest of the bark possessed the highest antiradical activity with IC50 values of 64.00 ± 0.59 and 67.00 ± 1.09 μg/mL, respectively. Harvest III of leaves showed the best inhibition of lipid peroxidation (IC50 = 1.48 ± 0.04 μg/mL). Leaf samples of F. carica showed also the best antiproliferative activity in comparison with bark and woody part of F. carica.
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