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Bidirectional recurrent neural network approach for predicting cervical cancer recurrence and survival.
Sci Rep
December 2024
School of Engineering and Technology, Sunway University, No. 5, Jalan Universiti, Bandar Sunway, Petaling Jaya, 47500, Selangor Darul Ehsan, Malaysia.
Cervical cancer is a deadly disease in women globally. There is a greater chance of getting rid of cervical cancer in case of earliest diagnosis. But for some patients, there is a chance of recurrence.
View Article and Find Full Text PDFOnset and predictors of first-line antiretroviral therapy treatment failure among children in Ethiopia: a systematic review and meta-analysis.
BMC Pediatr
December 2024
Department of Midwifery, College of Health Sciences, Debre Markos University, Debre Markos, Ethiopia.
Introduction: The emergence of First-line Antiretroviral Therapy (ART) regimens fails; it necessitates the use of more costly and less tolerable second-line medications. Therefore, it is crucial to identify and address factors that increase the likelihood of first-line ART regimen failure in children. Although numerous primary studies have examined the incidence of first-line ART failure among HIV-infected children in Ethiopia, national-level data on the onset and predictors remain inconsistent.
View Article and Find Full Text PDFThe second phase of tumor invasion driven by immune cells: A study on doxorubicin-loaded PLG nanoparticles.
J Control Release
December 2024
D. Mendeleev University of Chemical Technology of Russia, Miusskaya pl. 9, 125047, Moscow, Russia. Electronic address:
Poly(lactide-co-glycolide) (PLG) nanoparticles loaded with doxorubicin have reached phase-I clinical trials for treating advanced solid tumors. This study explores cell hitchhiking, where nanoparticles associate with blood cells and investigates the impact on pharmacokinetics and tumor migration. Previous findings highlighted the early post-injection phase dominated by nonspecific nanoparticle-cell interactions and burst release.
View Article and Find Full Text PDFMore twins expected in low-income countries with later maternal ages at birth and population growth.
Hum Reprod
December 2024
Laboratory of Fertility and Well-Being, Max Planck Institute for Demographic Research, Rostock, Germany.
Study Question: How are the changing maternal age structure and population growth expected to shape future twinning rates in low-income countries?
Summary Answer: With maternal age at birth projected to shift toward older ages, twinning rates are also estimated to increase in most low-income countries by 2050 and even more by 2100.
What Is Known Already: Many of the sub-Saharan African and South Asian countries are undergoing, and projected to further experience, the shift of maternal age at birth to older ages. Advanced maternal age is a well-established predictor of multiple births at the individual level, but currently, it is unknown how the changes in maternal age distribution are associated with the changes in twinning rates at the population level in low-income countries.
An explainable predictive model for anxiety symptoms risk among Chinese older adults with abdominal obesity using a machine learning and SHapley Additive exPlanations approach.
Front Psychiatry
December 2024
Operations Management and External Communications Department, The Thirteenth People's Hospital of Chongqing, Chongqing, China.
Background: Early detection of anxiety symptoms can support early intervention and may help reduce the burden of disease in later life in the elderly with abdominal obesity, thereby increasing the chances of healthy aging. The objective of this research is to formulate and validate a predictive model that forecasts the probability of developing anxiety symptoms in elderly Chinese individuals with abdominal obesity.
Method: This research's model development and internal validation encompassed 2,427 participants from the 2017-2018 Study of the Chinese Longitudinal Healthy Longevity Survey (CLHLS).
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