Objective: To report successful treatment by laparoscopically assisted biomaterial graft for reconstruction in patients with congenital atresia of the uterine cervix and vagina.
Design: Technique and instrumentations.
Setting: University-based tertiary care hospital.
Patient(s): An 18-year-old woman with vaginal agenesis and cervical dysgenesis and a 13-year-old woman with vaginal agenesis and cervical agenesis, both patients with a functional uterus.
Intervention(s): Creation of a neovagina by vaginal procedure and laparoscopically assisted biomaterial graft for uterovaginal anastomosis was performed in all patients.
Main Outcome Measure(s): All surgical findings were carefully reviewed to determine the anatomic characteristics of the malformed cervix. Subsequent follow-up was done by referring physicians.
Result(s): Uterovaginal continuity was established successfully in both patients, and all of the women were menstruating normally. Granulomatous polyps occurred in one patient, and this condition was successfully managed. At 6-month follow-up, mean vaginal length was 12 cm and ≥ 80% of neovaginal epithelium was iodine positive in both patients. Unimpeded menstrual flow continued after 4 years of follow-up in one patient and 5 years of follow-up in the other patient.
Conclusion(s): A combined laparoscopic and vaginal procedure with biomaterial graft could be an effective alternative in selected women with atresia of cervix and vagina.
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http://dx.doi.org/10.1016/j.fertnstert.2013.08.046 | DOI Listing |
J Appl Biomater Funct Mater
January 2025
Department of Neurosurgery, Neurocenter of South Switzerland, Ente Ospedaliero Cantonale, Lugano, Switzerland.
Introduction: Intensive research is dedicated to the development of novel biomaterials and medical devices to be used as grafts in reconstructive surgery, with the purpose of enhancing their therapeutic effectiveness, safety, and durability. A variety of biomaterials, from autologous bone to polymethylmetacrylate, polyether ether ketone, titanium, and calcium-based ceramics are used in cranioplasty. Porous hydroxyapatite (PHA) is reported as a possible material for bone reconstruction, with good signs of biocompatibility, osteoconductive and osteointegrative properties.
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January 2025
Department of Biochemistry, Institute for Biological Research "Siniša Stanković"-National Institute of the Republic of Serbia, University of Belgrade, Bulevar despota Stefana 142, 11060 Belgrade, Serbia.
Novel ferrite/polyurethane nanocomposites were synthesized using the in situ polymerization method after the addition of different spinel nanoferrite particles (copper, zinc, and copper-zinc) and examined as potential coatings for medical devices and implants in vascular tissue engineering. The influence of the nanoferrite type on the structure and functional characteristics of the polyurethane composites was investigated by FTIR, SWAXS, AFM, TGA, DSC, nanoindentation, swelling behavior, water contact angle, and water absorption measurements. Biocompatibility was evaluated by examining the cytotoxicity and adhesion of human endothelial cells and fibroblasts onto prepared composites and performing a protein adsorption test.
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January 2025
Department of Engineering and Materials Science and Transportation, University of Seville, 41092 Seville, Spain.
The necessity to mitigate the intrinsic issues associated with tissue or organ transplants, in order to address the rising prevalence of diseases attributable to increased life expectancy, provides a rationale for the pursuit of innovation in the field of biomaterials. Specifically, biopolymeric aerogels represent a significant advancement in the field of tissue engineering, offering a promising solution for the formation of temporary porous matrices that can replace damaged tissues. However, the functional characteristics of these materials are inadequate, necessitating the implementation of matrix reinforcement methods to enhance their performance.
View Article and Find Full Text PDFMolecules
January 2025
Laboratório de Bioengenharia, Universidade Federal de Itajubá, Itabira 35903-087, Minas Gerais, Brazil.
Fibroin, a protein extracted from silk, offers advantageous properties such as non-immunogenicity, biocompatibility, and ease of surface modification, which have been widely utilized for a variety of biomedical applications. However, in vivo studies have revealed critical challenges, including rapid enzymatic degradation and limited stability. To widen the scope of this natural biomacromolecule, the grafting of polymers onto the protein surface has been advanced as a platform to enhance protein stability and develop smart conjugates.
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January 2025
Department of Periodontology, Dental Research Division, Guarulhos University, Guarulhos 07023-070, Brazil.
Objective: The objective of this study was to evaluate autologous platelet-rich fibrin (PRF) membrane weights and measurements after production by different centrifuges. Moreover, the values obtained with blood cellular components were correlated.
Methods: Twelve systemically healthy participants underwent dental implant surgery associated with PRF membranes as the graft biomaterial at the implant site.
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