Aim: The transparency of implementation of the newborn hearing screening system in Germany is analysed. For this purpose it has been tested whether the current state can be retained and evaluated by using public accessible information channels.
Methods: A selective document analysis with subsequent assessment of the federal states was performed. In the form of a scoring system an assessment approach has been developed based on defined comparison criteria. The selective document analysis was characterised by including only documents which were detected through the internet and medical databases by using defined search terms.
Results: A complete survey of the current state of guideline implementation is not available by using public accessible information. The assessment of the federal states reveals an extremely heterogeneous situation with regard to the transparency of the implementation process in Germany. Bavaria has the highest score with 37 points, while Bremen has the lowest score with 3 points. Overall, the supply of information to experts is better constituted compared to that to the population, and respectively, the newborn's parents.
Conclusion: A meaningful evaluation of the implementation processes in the federal states up to now is urgently required. This is necessary both to optimise the process and to achieve the highest possible quality among patient-centred care structures nationwide.
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http://dx.doi.org/10.1055/s-0033-1351238 | DOI Listing |
Acta Crystallogr B Struct Sci Cryst Eng Mater
February 2025
Novosibirsk State University, Pirogova 1, Novosibirsk 630090, Russian Federation.
High-pressure and low-temperature structural changes in the ferroelectric phase of (R)-3-quinuclidinol are analysed. The changes in unit-cell volume and parameters are continuous both on cooling and under increasing pressure. The anisotropy of the structural strain, however, is found to be different.
View Article and Find Full Text PDFJAMA Netw Open
January 2025
Center of Data and Knowledge Integration for Health, Gonçalo Moniz Institute, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Importance: Congenital Zika syndrome (CZS) can lead to a range of developmental and neurological issues, which increases the risk of early death. However, the all-cause and cause-specific mortality in children with CZS in the first 5 years of life remain unknown.
Objective: To compare the hazard of all-cause and cause-specific mortality before age 5 years among children with and without CZS in Brazil.
Dokl Biochem Biophys
January 2025
Ryazan State Medical University, Ryazan, Russian Federation.
Introduction: Breast cancer resistance protein (BCRP) is an efflux membrane transporter that controls the pharmacokinetics of a large number of drugs. Its activity may change when taking some endo- and exogenous substances, thus making it a link in drug interactions.
Aim: The aim of the study was to develop a methodology for testing drugs for belonging to BCRP substrates and inhibitors in vitro.
Dokl Biochem Biophys
January 2025
Kazan Institute of Biochemistry and Biophysics, Federal Research Center "Kazan Scientific Center of the Russian Academy of Sciences,", 420111, Kazan, Russia.
Cytochromes of the P450 superfamily are widespread in nature; they were found in all studied aerobic organisms. Although the degree of similarity between cytochromes P450 of different families is low, all enzymes of this superfamily have similar tertiary structures. In addition, all cytochromes P450, including enzymes of the CYP74 clan, contain substrate recognition sites in their sequences, which form the catalytic center.
View Article and Find Full Text PDFDokl Biochem Biophys
January 2025
State Research Center-Burnasyan Federal Medical Biophysical Center of Federal Medical Biological Agency, 123098, Moscow, Russia.
Background: The effects of ionizing radiation (IR) involve a highly orchestrated series of events in cells, including DNA damage and repair, cell death, and changes in the level of proliferation associated with the stage of the cell cycle. A large number of existing studies in literature have examined the activity of genes and their regulators in mammalian cells in response to high doses of ionizing radiation. Although there are many studies, the research in effect of low doses of ionizing radiation remains limited.
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