Preventing pancreatitis after endoscopic retrograde cholangiopancreatography.

Gastrointest Endosc Clin N Am

Division of Gastroenterology, University of Michigan Medical Center, 3912 Taubman Center, Ann Arbor, MI 48109, USA.

Published: October 2013

Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis is a common and potentially devastating complication of ERCP. Advances in risk stratification, patient selection, procedure technique, and prophylactic interventions have substantially improved the endoscopists' ability to prevent this complication. This article presents the evidence-based approaches to preventing post-ERCP pancreatitis and suggests timely research questions in this important area.

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http://dx.doi.org/10.1016/j.giec.2013.06.003DOI Listing

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  • This study compared two alternative techniques, transpancreatic sphincterotomy (TPS) and precut sphincterotomy (PCS), for accessing the biliary tree during difficult ERCP procedures.
  • TPS showed higher successful cannulation rates (86.5%) compared to PCS (69.7%), but both were lower than the standard sphincterotomy control group (92.4%).
  • Despite higher cannulation success, TPS was associated with more adverse events (24.1%) compared to PCS (18.8%) and the control group (15.5%), with increased rates of pancreatitis and perforation in the TPS group.
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Introduction: Post-endoscopic retrograde cholangiopancreatography pancreatitis (PEP) is the most common serious adverse event after endoscopic retrograde cholangiopancreatography (ERCP). Although retrospective models to predict PEP have shown promise, their real-world applicability remains uncertain. Thus, we used prospectively derived cohort data to validate current prediction models.

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