AI Article Synopsis
- The study investigates how combining hydrogen peroxide (H2O2) and proanthocyanidin boosts antibacterial effectiveness against harmful bacteria like Streptococcus mutans and Porphyromonas gingivalis.
- In the presence of proanthocyanidin, the bactericidal action of H2O2, when exposed to light (specifically 405 nm), becomes much stronger than when using H2O2 alone.
- The research suggests that the interaction between photo-irradiated proanthocyanidin and H2O2 generates hydroxyl radicals, which disrupt the bacterial cell membranes, enhancing bacterial sensitivity to the disinfection treatment.
Article Abstract
The in vitro antibacterial activity of the hydroxyl radical generation system by the photolysis of H2O2 in combination with proanthocyanidin, which refers to a group of polyphenolic compounds, was examined. Bactericidal activity of photo-irradiated H2O2 at 405 nm against Streptococcus mutans, a major pathogen of dental caries, was augmented in the presence of proanthocyanidin, whose bactericidal effect by itself was very poor, in a concentration-dependent manner. This combination was also proven effective against Porphyromonas gingivalis, a major pathogen of periodontitis. It is speculated that H2O2, generated from photo-irradiated proanthocyanidin around the bacterial cells, is photolyzed to the hydroxyl radical, which would in turn affect the membrane structure and function of the bacterial cells, resulting in augmented sensitivity of bacterial cells to the disinfection system utilizing the photolysis of H2O2. The present study suggests that the combination of H2O2 and proanthocyanidin works synergistically to kill bacteria when photo-irradiated.
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| http://dx.doi.org/10.4265/bio.18.137 | DOI Listing |
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