AI Article Synopsis
- Identified AnsP1 as the sole transporter for aspartate in the bacterium Mycobacterium tuberculosis.
- A mutant strain lacking AnsP1 showed impaired nitrogen assimilation from aspartate, impacting its metabolic function.
- The mutant's reduced virulence in hosts indicates that aspartate is crucial for M. tuberculosis colonization and survival.
Article Abstract
Here we identify the amino acid transporter AnsP1 as the unique aspartate importer in the human pathogen Mycobacterium tuberculosis. Metabolomic analysis of a mutant with an inactive AnsP1 revealed that the transporter is essential for M. tuberculosis to assimilate nitrogen from aspartate. Virulence of the AnsP1 mutant is impaired in vivo, revealing that aspartate is a primary nitrogen source required for host colonization by the tuberculosis bacillus.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3856356 | PMC |
| http://dx.doi.org/10.1038/nchembio.1355 | DOI Listing |
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