Fluorescent and radiolabeled triphenylphosphonium probes for imaging mitochondria.

Chem Commun (Camb)

Center for Advanced Medical Imaging Sciences, Massachusetts General Hospital, 149 13th Street, Charlestown, MA 02129, USA.

Published: November 2013

AI Article Synopsis

  • Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are innovative probes designed to target mitochondria and vary in their spectral properties.
  • They can be labeled with the radioactive isotope fluorine-18 ([(18)F]), which is useful for PET/CT imaging.
  • This technology enables the detection of issues related to blood flow in the heart, specifically cardiac perfusion deficits.

Article Abstract

Triphenylphosphonium-fluorochromes (TPP-fluorochromes) are a new class of spectrally variable, mitochondrially targeted probes, with an [(18)F] labeling option which, when enabled, allows imaging of a cardiac perfusion deficit using PET/CT.

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Source
http://dx.doi.org/10.1039/c3cc45802dDOI Listing

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