We determined circulating T helper, T regulatory and ICOS+T regulatory as well as DC cell counts in 29 patients with cerebral gliomas. Samples from patients with gliomas vs. healthy controls and from patients with glioblastomas vs. patients with glioma WHO grades I-III contained significantly (p<0.05) decreased numbers of total as well as mature, i.e. myeloid and plasmacytoid DCs. Patients with glioblastomas demonstrated significantly lower values of CD4+ as well as an increased fraction of ICOS+T regulatory/CD4+ cells. Higher CD4+ cell counts (≥225 cells/μl, median) were associated with improved survival in glioblastomas.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jneuroim.2013.09.001 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Repetitive Acinetobacter baumannii pneumonia induces infection tolerance in mice.
Microb Pathog
December 2024
College of Pulmonary and Critical Care Medicine, 8th Medical Center of Chinese PLA General Hospital (PLA Medical School), Beijing, China. Electronic address:
Article Synopsis
- - Some long-term lung infection patients show a phenomenon known as pathogen tolerance, prompting researchers to explore this in a mouse model of pneumonia by infecting mice with Acinetobacter baumannii multiple times.
- - Results indicated that after three infections, inflammatory factors decreased and lung tissue damage lessened, suggesting a form of tolerance developed in these mice.
- - Further analysis revealed increased expression of genes related to T cell regulation and a rise in regulatory T cells, indicating that repeated infections may lead to immune suppression that contributes to this tolerance.
Assessment of pDCs functional capacity upon exposure to tumor-derived soluble factors.
Methods Cell Biol
October 2024
Sotio, Prague, Czech Republic. Electronic address:
Article Synopsis
- * Aside from their viral defense role, pDCs also have implications in autoimmunity, inflammation, and cancer, often exhibiting functional defects in tumor environments, leading to a supportive role for tumors.
- * The text outlines a method to evaluate how tumor-derived substances affect the functionality of pDCs, which can also be adjusted to study the effects of other soluble factors on pDC behavior.
Complement factor H is an ICOS ligand modulating Tregs in the glioma microenvironment.
Cancer Immunol Res
October 2024
Lund University, Malmö, Sweden.
Article Synopsis
- * This study found that complement factor H (FH) acts as an ICOS ligand, enhancing Treg survival and function while increasing TGF-beta and IL-10 secretion, which suppresses T-cell activity.
- * Analysis in mouse models and patient data revealed that higher FH levels are linked to more Tregs and poorer patient outcomes, indicating that targeting FH could improve glioma treatment and prognosis.
DSP-0509, a TLR7 agonist, exerted synergistic anti-tumor immunity combined with various immune therapies through modulating diverse immune cells in cancer microenvironment.
Front Oncol
September 2024
Cancer Research Unit, Sumitomo Pharma Co., Ltd., Osaka, Japan.
Toll-like receptor 7 (TLR7) acts as a crucial component of the innate immune system. Upon TLR7 binding to its ligand, myeloid cells, including dendritic cells (DCs) and macrophages, are activated and play vital roles in initiating adaptive immunity. Consequently, TLR7 agonists have been employed in cancer immunotherapy.
View Article and Find Full Text PDFArticle Synopsis
- DOCK8 deficiency is a primary immunodeficiency caused by mutations in exon 45 of the DOCK8 gene, leading to symptoms like high serum IgE, eczema, and increased infections.
- Using CRISPR/Cas9, researchers created a mouse model with the same exon 45 mutation to study its effects on T cell behavior.
- The study found that the mutation affects T cell homeostasis, disrupts regulatory T cell development, alters glycolysis in CD4 T cells, and promotes a Th2 response upon infection, providing insights for potential treatments.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!