AI Article Synopsis
- Magmas is a nuclear gene that encodes the Tim16 subunit of the mitochondrial import inner membrane translocase and is found to be overexpressed in many human pituitary adenomas as well as in some mouse models.
- Magmas expression in rat pituitary adenoma cell lines shows an inverse correlation with cell response to staurosporine, meaning higher levels of Magmas are associated with lower apoptosis and increased cell viability.
- The study highlights that overexpression of Magmas in specific pituitary adenoma cells enhances cell survival and protects against staurosporine-induced apoptosis, indicating its potential role in pituitary adenoma development.
Article Abstract
Magmas is a nuclear gene that encodes for the mitochondrial import inner membrane translocase subunit Tim16. Magmas is overexpressed in the majority of human pituitary adenomas and in a mouse ACTH-secreting pituitary adenoma cell line. Here we report that Magmas is highly expressed in two out of four rat pituitary adenoma cell lines and its expression levels inversely correlate to the extent of cellular response to staurosporine in terms of apoptosis activation and cell viability. Magmas over-expression in rat GH/PRL-secreting pituitary adenoma GH4C1 cells leads to an increase in cell viability and to a reduction in staurosporine-induced apoptosis and DNA fragmentation, in parallel with the increase in Magmas protein expression. These results indicate that Magmas plays a pivotal role in response to pro-apoptotic stimuli and confirm and extend the finding that Magmas protects pituitary cells from staurosporine-induced apoptosis, suggesting its possible involvement in pituitary adenoma development.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3775776 | PMC |
| http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0075194 | PLOS |
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