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Co-stimulating the left vmPFC compensates for apathy after levodopa withdrawal in Parkinson's patients with STN DBS.
Parkinsonism Relat Disord
December 2024
The Nash Family Center for Advanced Circuit Therapeutics at the Icahn School of Medicine at Mount Sinai West, New York, NY, 10019, United States.
Introduction: Subthalamic nucleus deep brain stimulation (STN DBS) improves motor symptoms of Parkinson's disease (PD), but its effect on motivation is controversial. Apathy, the lack of motivation, commonly occurs in PD and is often exacerbated after surgery and its concomitant levodopa reduction. Apathy and reward processing are associated with the ventromedial prefrontal cortex (vmPFC), which standard targeting strategies avoid by targeting the dorsolateral STN.
View Article and Find Full Text PDFReliability of the documented blood group in motor vehicle driving license in Kerala, India - A public health concern?
J Family Med Prim Care
November 2024
Achutha Menon Centre for Health Science Studies, Sree Chitra Tirunal Institute For Medical Sciences and Technology, Trivandrum, Kerala, India.
Introduction: Blood groups documented in motor vehicle driving licenses can provide quick information during emergency transfusion requirements and imbibe self-awareness about one's blood group. The tendency of applicants to mention blood groups without verification during the application may result in incorrect documentation of blood groups in their driving license. The study aims to assess the reliability of the blood groups in driving licenses and their association with sociodemographic variables.
View Article and Find Full Text PDFIntroduction: Latina, Latino, Latinx, Latine, Hispanic, or of Spanish origin+ (LHS+) women face higher cervical cancer risks, incidence, and mortality compared to non-Hispanic White women. These disparities are attributable to socioeconomic factors, limited access to health care, language and cultural barriers, and negative health care experiences.
Methods: We used the Kern model to design, implement, and evaluate a workshop to educate medical students and health care professionals on cervical cancer disparities among LHS+ women and culturally competent communication skills.
Equitable and effective clinical guidance development and dissemination: trauma aims to lead the way.
Trauma Surg Acute Care Open
December 2024
Department of Surgery, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Thirty-four per cent of deaths among Americans aged 1-46 are due to injury, and many of these deaths could be prevented if all hospitals performed as well as the highest-performing hospitals. The Institute of Medicine and the National Academies of Science, Engineering and Medicine have called for learning health systems, with emphasis on clinical practice guidelines (CPGs) as a means of limiting preventable deaths. Reduction in mortality has been demonstrated when evidence-based trauma CPGs are adhered to; however, guidelines are variably updated, redundant, absent, inaccessible, or perceived as irrelevant.
View Article and Find Full Text PDFAre noradrenergics combined with antimuscarinics the future pharmacologic treatment for obstructive sleep apnea? A systematic review and meta-analysis of randomized controlled trials.
Sleep Breath
December 2024
Faculty of Medicine, Assiut University, Assiut, Egypt.
Purpose: Noradrenergics and antimuscarinics have been proposed as future pharmacotherapy for obstructive sleep apnea (OSA). However, the available randomized controlled trials (RCTs) showed heterogeneous results regarding the safety and efficacy of the combined regimen in OSA. Therefore, we performed this meta-analysis from the published RCTs to clarify this conflicting evidence.
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