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CD39/CD73 and the imbalance of Th17 cells and regulatory T cells in allergic asthma. | LitMetric

AI Article Synopsis

  • CD4+CD25+Foxp3+ regulatory T cells (Tregs) help maintain balance in the immune response, while Th17 cells drive inflammation; an imbalance between these cell types is linked to allergic asthma.
  • The study revealed that patients with moderate to severe asthma had more IL-17+Foxp3+ T cells and showed a deficiency in CD39, which is important for regulating Th17 cells.
  • Enhanced CD39 activity could potentially help restore balance between Tregs and Th17 cells, suggesting a therapeutic target for asthma management.

Article Abstract

In the immune system, CD4+CD25+Foxp3+ regulatory T cells (Tregs) maintain self‑tolerance and Th17 cells mediate inflammatory responses. CD39 is expressed on the surface of a subset of naturally occurring human Tregs that are important in constraining pathogenic Th17 cells. Additional studies have shown that Tregs differentiate into interleukin‑17 (IL‑17)+Foxp3+ T cells. Our previous study indicated an imbalance of Th17 and Tregs in allergic asthma; however, the underlying mechanisms remain poorly understood. Using quantitative PCR (qPCR), CD39 and CD73 mRNA levels in CD4+ T cells were investigated. Flow cytometry was used to analyze the proportion of IL‑17+Foxp3+ T cells, and CD39 and CD73 expressed by CD4+ T cells and Tregs in the peripheral blood of the subjects. The results of the present study demonstrated an increased frequency of CD4+Foxp3+IL‑17+ T cells in moderate to severe asthma. A deficiency in CD39 expressed on the surface of CD4+ T cells and Tregs was observed in asthma patients. The expression of CD39 and CD73 on the surface of CD4+ T cells and Tregs was negatively correlated with the number of Th17 cells. These results indicated that the plasticity of Tregs transforming to IL‑17+Foxp3+CD4+ T cells, the reduced frequency of CD39+ Tregs and less effective suppression of IL‑17 production by residual CD39+ Tregs leads to an imbalance of Th17 and Tregs in asthma. Therefore, enhanced CD39 activity is hypothesized to prevent the progression of asthma.

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Source
http://dx.doi.org/10.3892/mmr.2013.1692DOI Listing

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