AI Article Synopsis
- Seven new protopanaxatriol type saponins (1-7) were isolated from the root extract of Panax notoginseng, demonstrating protective effects against mitochondrial oxidative stress induced by antimycin A.
- Their structures were identified using various chemical and spectroscopic techniques, including IR, HRESI-TOF-MS, and NMR.
- Compounds 4, 6, and 7 exhibited particularly strong protective effects against cell injury in L6 cells due to antimycin A.
Article Abstract
Seven new protopanaxatriol type saponins, 20S-sanchirhinosides A1 (1), A2 (2), A3 (3), A4 (4), A5 (5), and A6 (6), and sanchirhinoside B (7) were obtained as minor constituents from the root extract of Panax notoginseng (Burkill, F. H. Chen), which showed protection effects against antimycin A induced mitochondrial oxidative stress. Their structures were elucidated by chemical and spectroscopic methods (IR, HRESI-TOF-MS, 1D and 2D NMR). Among them, compounds 4, 6 and 7 showed significant protective effects against antimycin A-induced L6 cell injury.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6270354 | PMC |
| http://dx.doi.org/10.3390/molecules180910352 | DOI Listing |
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