Objective: To describe a new scheme of skin cover in epispadias repair to improve the aesthetic results and minimize complications.
Patients And Methods: In the last 4 years, 7 male continent epispadias (aged 2-5 years) undergoing Cantwell-Ransley repair received a new technique of skin cover. After a U-shaped incision along the margin of urethral plate, a transverse incision beginning at the margin of urethral plate 7-10 mm proximal to the corona was carried along the prepucial edge upto the corresponding point at urethral plate margin on the other side. The prepuce was split into a dorsal flap attached to the corona and a ventral flap continuous with penile skin. After subdartos degloving, incision through median raphe upto penoscrotal junction bifurcated the penile skin-dartos complex. After Cantwell-Ransley repair, reverse advancement of inner prepucial flap provided skin cover to most of the ventral aspect of penile shaft. Dorsal midline union of bifurcated penile skin-dartos flaps provided dorsolateral cover. At ventral midline, limited joining of penile skin-dartos flaps at penoscrotal junction and anchoring to corpus spongiosum created penoscrotal angle with shaft cover at penoscrotal junction. Lateral margins of dorsal and ventral skin cover were joined.
Results: There was no flap necrosis, penile rotation, or recurrent chordee. Symmetrical distribution of skin and automatic creation of partial prepucial hood provided gratifying aesthetic appearance. One coronal sulcus fistula was repaired.
Conclusion: This simple and reproducible skin management scheme in epispadias repair helps in providing aesthetically pleasing skin cover, penoscrotal angle, penopubic angle, and prepucial hood with minimum complications.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1016/j.urology.2013.06.069 | DOI Listing |
JCO Precis Oncol
January 2025
Department of Medical Oncology, Hokkaido University Hospital, Sapporo, Hokkaido, Japan.
Purpose: Precision medicine plays an important role in the treatment of patients with advanced melanoma. Despite its high incidence in White patients, advanced melanoma is rare in Asian countries, hampering prospective clinical trials targeting the Asian population. This retrospective study aimed to elucidate the real-world molecular diagnoses and outcomes of Japanese patients with melanoma using comprehensive genome profiling (CGP).
View Article and Find Full Text PDFPLoS One
January 2025
Department of Dermatology, Hanoi Medical University, Hanoi, Vietnam.
Objective: Chronic spontaneous urticaria (CSU) is a challenging condition that significantly impacts the affected patients. This study aimed to evaluate the quality of life (QoL) among patients with CSU in Vietnam and identify factors associated with QoL.
Methods: A cross-sectional study was conducted at the Vietnam National Dermatology and Venereology Hospital from June 2023 to March 2024.
J Gastrointest Oncol
December 2024
Department of Medical Oncology and Radiation Sickness, Peking University Third Hospital, Beijing, China.
Background: Regorafenib, approved in China for the third-line treatment of patients with metastatic colorectal cancer (mCRC), targets multiple tyrosine kinases. We retrospectively evaluated the efficacy and safety of regorafenib, both as monotherapy and in combination with capecitabine or immune checkpoint inhibitors (ICIs), as a second-line treatment for patients unable to access hospital-based care due to limited hospital visits during the coronavirus disease 2019 (COVID-19) pandemic.
Methods: Retrospective analysis was conducted on individual patient data from Peking University Third Hospital, covering the period from January 2020 to September 2023.
J Cosmet Dermatol
January 2025
Małopolska Centre of Biotechnology, Stem Cell Laboratory, Jagiellonian University, Kraków, Poland.
Objective: To present and analyze eight clinical cases illustrating the use of rose stem cell-derived exosomes (RSCEs) in treating various dermatological conditions and to review current literature on plant-derived exosomes in medicine and dermatology.
Background: RSCEs possess low cytotoxicity, high biocompatibility, and effective cellular uptake, making them promising agents for dermatological therapies. A literature review included in the introduction and discussion covers the broader role of plant-derived exosomes, highlighting their therapeutic potential in skin treatment.
Int J Biol Macromol
January 2025
Polymers and Pigments Department, Chemical Industries Research Institute, National Research Centre, Dokki, Giza 12622, Egypt.
Integrating nanotechnology with tissue engineering has revolutionized biomedical sciences, enabling the development of advanced therapeutic strategies. Tissue engineering applications widely utilize alginate due to its biocompatibility, mild gelation conditions, and ease of modification. Combining different nanomaterials with alginate matrices enhances the resulting nanocomposites' physicochemical properties, such as mechanical, electrical, and biological properties, as well as their surface area-to-volume ratio, offering significant potential for tissue engineering applications.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!