AI Article Synopsis
- The study aimed to assess the effectiveness of rapid disintegration tablets in enhancing the performance of solid dispersions for albendazole.
- Rapid disintegration of tablets was found to significantly boost the bioavailability of albendazole.
- Testing in dogs indicated that albendazole's plasma levels increased notably when administered via rapid disintegration tablets versus traditional forms.
Article Abstract
The main objectives of this study were (a) to evaluate the in vitro performance of the rapid disintegration tablets as a way to improve the solid dispersions and (b) to study the in vivo pharmacokinetics of the albendazole modified formulation in dogs. Rapid disintegration of tablets seems to be a key factor for efficiency of solid dispersions with regard to improvement of the albendazole bioavailability. The in vivo assays performed on dogs showed a marked increase in drug plasma exposure when albendazole was given in solid dispersions incorporated into rapid disintegration tablets compared with conventional solid dosage form.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3766998 | PMC |
| http://dx.doi.org/10.1155/2013/920305 | DOI Listing |
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