With the goal of eventually synthesizing [5]radialene (3), the still missing member of the parent radialene hydrocarbons, we have prepared the pentaacetates 21 and 31, the pentabromide 29 and the hexabromide 32. In principle these should be convertible by elimination reactions to the desired target molecule.
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http://dx.doi.org/10.3762/bjoc.9.195 | DOI Listing |
Aim: This study was conducted to evaluate the in vitro effects of hydroxychloroquine (HCQ) on histone deacetylase (HDAC) enzyme activity and interleukin (IL)-6, IL-10, and tumor necrosis factor-alpha (TNF-α) expression. HDAC enzyme activity and the expression of inflammation markers were tested, with the presence of the HDAC inhibitor valproic acid, in human primary cell cultures prepared from two different tissues.
Material And Methods: Primary cell cultures were prepared.
Adv Sci (Weinh)
January 2025
Haiping Fang, School of Physics, East China University of Science and Technology, Shanghai, 20023, China.
The human visual nervous system excels at recognizing and processing external stimuli, essential for various physiological functions. Biomimetic visual systems leverage biological synapse properties to improve memory encoding and perception. Optoelectronic devices mimicking these synapses can enhance wearable electronics, with layered heterojunction materials being ideal materials for optoelectronic synapses due to their tunable properties and biocompatibility.
View Article and Find Full Text PDFChemistry
January 2025
Key Laboratory of Science and Technology of Eco-Textiles, Ministry of Education, College of Chemistry and Chemical Engineering, Donghua University, Shanghai, 201620, P. R. China.
We have developed an efficient synthesis of fluoroalkenes via tandem electrochemical dehalogenation-elimination protocol. The key step is the generation of carbon anion by electrochemical reductive dehalogenation of alkyl halides. Various gem-difluoroalkenes and monofluoroalkenes were prepared in moderate to good yields from α-difluoromethylated/α-trifluoromethylated benzyl halides.
View Article and Find Full Text PDFSci Prog
January 2025
Department of Industrial Engineering, UiT-The Arctic University of Norway, Narvik, Norway.
Background: Retail involves directly delivering goods and services to end consumers. Natural disasters and epidemics/pandemics have significant potential to disrupt supply chains, leading to shortages, forecasting errors, price increases, and substantial financial strains on retailers. The COVID-19 pandemic highlighted the need for retail sectors to prepare for crisis impacts on sales forecasts by regularly assessing and adjusting sales volumes, consumer behavior, and forecasting models to adapt to changing conditions.
View Article and Find Full Text PDFSmall
January 2025
Department of Environmental Science and Engineering, Xi'an Jiaotong University, Xi'an, 710049, P. R. China.
The preparation and modification of porous electrodes are an important component of the new generation electrochemical oxidation technology. Rapid preparation of porous electrodes can be easily achieved by synchronous oxygen bubble electrodeposition. However, according to the reaction mechanism of lead dioxide anodic electrodeposition, there is bound to be a competitive reaction of adsorbed hydroxyl radicals in the oxygen bubble template method, which means that synchronous OER impacts both the surface morphology and potentially the crystalline structure of the metal oxides.
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