AI Article Synopsis
- The study evaluated the effectiveness of a 24-core template-guided transperineal biopsy (TPB) for detecting prostate cancer in men who had previously negative biopsies.
- The research involved 50 men with specific criteria and found that prostate cancer was detected in 48% of them, with some cases being clinically insignificant.
- The TPB procedure was deemed safe, with minimal complications reported, suggesting it as a viable option for men with prior negative results.
Article Abstract
Objective: To evaluate the prostate cancer (PCa) detection rate, PCa location, PCa significance and complications of a standardized 24-core template-guided transperineal biopsy (TPB) approach in patients with at least two negative transrectal biopsies.
Methods: We prospectively recruited 50 men who had at least two negative transrectal ultrasound-guided extended biopsies in the past 24 months, a prostate-specific antigen (PSA) < 20 ng/mL, a prostate volume < 100 mL, and life expectancy of at least 90 % at 10 years. All patients underwent a standardized 24-core template-guided TPB biopsy. The PCa detection rate, PCa location, PCa significance, and complications were recorded.
Results: Median age was 57.5 years and the median PSA level was 7.3 ng/ml. PCa was detected in 24 patients (48 %). The anterior zone was involved in 16 (32 %) PCa. Six PCa (25 %) were insignificant. Biopsy related complications occurred in 2 patients (4 %).
Conclusions: A 24-core TPB is a safe procedure with a high PCa detection rate. Few of the detected PCa are clinically insignificant. Men with at least two negative transrectal biopsies may be counseled to undergo TPB.
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| http://dx.doi.org/10.1007/s00508-013-0421-4 | DOI Listing |
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