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MYC rearrangements in HIV-associated large B-cell lymphomas: EUROMYC, a European retrospective study.
Blood Adv
February 2024
Department of Hematology, ASST Spedali Civili di Brescia, Brescia, Italy.
Large B-cell lymphoma (LBCL) carrying MYC rearrangement, alone or together with BCL2 and/or BCL6 translocations, have shown a poor prognosis when treated with rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) in the HIV population. Scanty data are available on the prevalence and prognostic impact of MYC rearrangements in HIV-associated LBCL. We conducted a retrospective study to evaluate the clinical effect of MYC rearrangement in HIV-associated LBCL.
View Article and Find Full Text PDFThe Clinicopathologic Features and Molecular Signatures of Blastoid High-Grade B Cell Lymphoma, Not Otherwise Specified.
Mod Pathol
December 2023
Department of Hematopathology, The University of Texas MD Anderson Cancer Center, Houston, Texas. Electronic address:
Article Synopsis
- A study of 55 cases of blastoid high-grade B-cell lymphoma (HGBL), not otherwise specified (NOS), was conducted to understand their characteristics compared to other types of HGBL, including 81 non-blastoid cases and 62 cases with MYC and BCL2 rearrangements (double/triple-hit lymphoma).
- Patients with blastoid HGBL-NOS had common features with other groups but showed a higher frequency of previous low-grade B-cell lymphoma, bone marrow involvement, and BCL2 rearrangement, with a significant presence of MYC rearrangement linked to more aggressive disease and worse survival rates.
- The research highlighted that blastoid HGBL-NOS, despite having similarities to other types
Chromosomal Aberration t(14;17)(q32;q21) Simultaneously Activates HOXB5 and miR10a in Triple-Hit B-Cell Lymphoma.
Biomedicines
June 2023
Department of Human and Animal Cell Lines, Leibniz-Institute DSMZ-German Collection of Microorganisms and Cell Cultures, Inhoffenstr. 7B, 38124 Braunschweig, Germany.
, and are major oncogenes in B-cell lymphoma. Their aberrant activation frequently occurs via chromosomal translocations which juxtapose light or heavy chain immunoglobulin (IG) genes to and or fuse diverse partner genes with . So-called double-hit lymphomas usually carry and rearrangements, while triple-hit lymphomas additionally bear -fusions.
View Article and Find Full Text PDFA survey evaluating hematology physicians’ perspectives on central nervous system prophylaxis.
Blood Res
June 2023
Department of Haematology, Koç University, Medical Faculty, İstanbul, Turkey.
Background: Central nervous system (CNS) prophylactic options for diffuse large B-cell lymphoma (DLBCL) are administered differently in most centers. Unfortunately, there is still not a consensus on which patients, which regimen, for how many cycles, and when prophylaxis should be administered. Thus, this remains an unmet clinical need.
View Article and Find Full Text PDFTriple hit to the kidney-dual pathological crescentic glomerulonephritis and diffuse proliferative immune complex-mediated glomerulonephritis: A case report.
World J Clin Cases
November 2022
Department of Medicine, Wright State University, Dayton, OH 45409, United States.
Background: Anti-glomerular basement membrane (GBM) disease is a rare rapidly progressive glomerulonephritis, frequently associated with alveolar hemorrhage in the lungs and involving the kidney by crescentic glomerulonephritis. It has been described in association with other glomerulonephritides [such as anti-neutrophilic antibody (ANCA)-glomerulonephritis, membranous nephropathy, and immunoglobulin (Ig)A nephropathy].
Case Summary: Herein we present an unusual case of concurrent anti-GBM disease, ANCA-associated crescentic glomerulonephritis and diffuse proliferative immune complex mediated glomerulonephritis with predominant staining for IgA and C3 by immunofluorescence.
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