AI Article Synopsis
- The study explored the in vitro antioxidant activity of two cyclodidepsipeptides, revealing their moderate antioxidant capabilities.
- A strong correlation was observed between DPPH-radical scavenging ability and total reducing power, indicating effective antioxidant action.
- The research suggests that the antioxidant mechanism primarily involves hydrogen atom abstraction from a specific position in the morpholinedione ring, marking the first report on the antioxidant properties of morpholine-2,5-dione derivatives.
Article Abstract
In vitro antioxidant activity of two cyclodidepsipeptides, 3-(2-methylpropyl)-6-(propan-2-yl)-4-methyl-morpholine-2,5-dione and 3,6-di(propan-2-yl)-4-methyl-morpholine-2,5-dione, was investigated. Our data indicate moderate antioxidant potentials of the two studied cyclodepsipeptides. A high correlation between 2,2-diphenyl-1-picrylhydrazyl (DPPH)-radical scavenging capacity and total reducing power were found. According to the density functional theory (DFT) calculations, the most probable mechanism of antioxidant action is hydrogen atom abstraction from the activated C-H group at 3-position in the morpholinedione ring. To the best of our knowledge this is the first report about the antioxidant properties of morpholine-2,5-diones derivatives.
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