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One-pot, Three-component Synthesis of Dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridine-2-yl-1,5-dihydrofuro[3,4-b]pyridine-2,3-dicarboxylate. | LitMetric

AI Article Synopsis

  • A one-pot reaction combines 2-aminopyridine, acetylenic esters, and alkyl isocyanides to produce new compounds.
  • The process yields tetraalkyl 4-(alkylamino)-2H-1,2'-bipyridine-2,3,5,6-tetracarboxylate and dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridin-2-yl-1,5-dihydrofuro[3,4-b]pyridine 2,3-dicarboxylate.
  • This reaction occurs under mild conditions and achieves good to high yields.

Article Abstract

A one-pot isocyanide-based three-component reaction of 2-aminopyridine and acetylenic esters with alkyl isocyanides afforded tetraalkyl 4-(alkylamino)-2H-1,2'-bipyridine-2,3,5,6-tetracarboxylate and dialkyl 4-(alkylamino)-7-alkoxy-5-oxo-1-pyridin-2-yl-1,5-dihydrofuro[3,4-b]pyridine 2,3-dicarboxylate in good to high yields under mild reaction conditions.

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