Nitroderivatives of catechol (NDCs) are reviewed with special emphasis on their complexes and applications. Binary, ternary and quaternary NDC complexes with more than 40 elements (aluminum, arsenic, boron, beryllium, calcium, cobalt, copper, iron, gallium, germanium, magnesium, manganese, molybdenum, niobium, rare earth elements, silicon, tin, strontium, technetium, thallium, titanium, uranium, vanadium, tungsten, zinc and zirconium) are discussed and the key characteristics of the developed analytical procedures - tabulated. The bibliography includes 206 references.
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Effect of intracerebral hydroxytyrosol and its nitroderivatives on striatal dopamine metabolism: A study by in vivo microdialysis.
Life Sci
August 2015
Department of Biochemistry and Molecular Biology, Faculty of Pharmacy, University of Seville, 41012 Seville, Spain. Electronic address:
Aims: The natural phenolic oil compound hydroxytyrosol (HTy) is widely studied because of its antioxidant and neuroprotective properties. Nitroderivatives of HTy have been studied in order to evaluate their putative effects on catechol-O-methyltransferase (COMT) activity.
Main Methods: To study its effect on dopamine metabolism, nitrohydroxytyrosol and its lipophilic derivatives (nitrohydroxytyrosyl acetate and ethyl nitrohydroxytyrosyl ether), were administered into the rat corpus striatum through a microdialysis probe.
Tau-derived-hexapeptide 306VQIVYK311 aggregation inhibitors: nitrocatechol moiety as a pharmacophore in drug design.
ACS Chem Neurosci
December 2013
School of Pharmacy, Health Sciences Campus, University of Waterloo, Waterloo, Ontario, Canada N2L 3G1.
The nitrocatechol derivatives tolcapone (1) and entacapone (2), used as adjunctive therapy in the treatment of Parkinson's disease, were investigated for their potential to inhibit the tau-derived-hexapeptide 306VQIVYK311. They were compared to small molecules that contain similar pharmacophores including the catechol derivatives (dopamine 3 and epinephrine 4), nitroderivatives (nifedipine 5 and chloramphenicol 6), nitrocatechol isomers (7 and 8), and a tolcapone derivative (13) lacking the nitrocatechol moiety. The aggregation kinetics by thioflavin S fluorescence assay indicates that both tolcapone (1) and entacapone (2) exhibit antiaggregation properties.
View Article and Find Full Text PDFNitroderivatives of catechol (NDCs) are reviewed with special emphasis on their complexes and applications. Binary, ternary and quaternary NDC complexes with more than 40 elements (aluminum, arsenic, boron, beryllium, calcium, cobalt, copper, iron, gallium, germanium, magnesium, manganese, molybdenum, niobium, rare earth elements, silicon, tin, strontium, technetium, thallium, titanium, uranium, vanadium, tungsten, zinc and zirconium) are discussed and the key characteristics of the developed analytical procedures - tabulated. The bibliography includes 206 references.
View Article and Find Full Text PDFEffect of substituents on complex stability aimed at designing new iron(III) and aluminum(III) chelators.
J Inorg Biochem
February 2009
Dipartimento di Scienze Chimiche, Centro Interdipartimentale per lo Studio dei Metalli in Medicina, Cittadella Universitaria, 09042 Monserrato-Cagliari, Italy.
The solution equilibria of iron(III) and aluminum(III) with two classes of hard ligands (catechol, salicylic acid and their nitro-derivatives) have been reliably studied by potentiometric, spectrophotometric and NMR spectroscopy. The effect of the nitro substituent on the binding properties of catechol and salicylic acid has been examined thoroughly. The inductive and resonance properties of the substituent that, as expected, lower the basicity of the phenolic and carboxylic groups, lead to a general decrease in both protonation and complex formation constants.
View Article and Find Full Text PDFRed wine-dependent reduction of nitrite to nitric oxide in the stomach.
Free Radic Biol Med
November 2007
Center for Neuroscience and Cell Biology and Faculty of Pharmacy, University of Coimbra, 3000 Coimbra, Portugal.
Nitrite may be a source for nitric oxide (*NO), particularly in highly acidic environments, such as the stomach. Diet products contribute also with reductants that dramatically increase the production of *NO from nitrite. Red wine has been attributed health promoting properties largely on basis of the reductive antioxidant properties of its polyphenolic fraction.
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