AI Article Synopsis
- - Gigantoxin I, derived from the sea anemone Stichodactyla gigantea, is recognized as the first natural toxin with epidermal growth factor (EGF)-like properties.
- - The study reveals that gigantoxin I interacts with TRPV1 channels, which are crucial for pain sensation and known to be targets of cnidaria venom.
- - It highlights a new pathway (EGFR/PLA2/AA/LOX) that indirectly activates TRPV1 channels through gigantoxin I, enhancing our understanding of both this toxin's effects and TRPV1 channel regulation.
Article Abstract
Gigantoxin I, isolated from sea anemone Stichodactyla gigantea, was previously described as the first epidermal growth factor (EGF)-like toxin from natural origin. In this study, we discovered the interaction between the transient receptor potential vanilloid subtype I (TRPV1) channels and gigantoxin I. The TRPV1 channel is a non-selective cation channel involved in pain sensation and is described as pharmacological target of cnidaria venom. Our results highlight the involvement of the epidermal growth factor receptor/phospholipaseA2/arachidonic acid/lipoxygenase (EGFR/PLA2/AA/ LOX) pathway in the indirect activation of TRPV1 channels by gigantoxin I. This is the first time that this pathway is described in the indirect activation of TRPV1 channels by toxins. This knowledge not only gives insights into the possible induced effects by this new group of toxins, but also leads to a better understanding of the regulatory mechanism of TRPV1 channels themselves.
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