AI Article Synopsis
- Magnetic resonance imaging (MRI) is crucial for cancer patient management, offering better contrast and sensitivity for identifying and staging tumors compared to other imaging techniques.
- About 40-50% of MRI scans use contrast agents, primarily based on the gadolinium ion, which is safely chelated to prevent toxicity.
- The effectiveness of these gadolinium-based contrast agents is influenced by factors like their molecular structure, concentration, and the conditions during imaging, affecting how they enhance visibility in scans.
Article Abstract
Magnetic resonance plays a leading role in the management of oncology patients, providing superior contrast resolution and greater sensitivity compared with other techniques, which enables more accurate tumor identification, characterization and staging. Contrast agents are widely used in clinical magnetic resonance imaging; approximately 40-50% of clinical scans are contrast enhanced. Most contrast agents are based on the paramagnetic gadolinium ion Gd3+, which is chelated to avoid the toxic effects of free gadolinium. Multiple factors such as molecule structure, molecule concentration, dose, field strength and temperature determine the longitudinal and transverse relaxation rates (R1 and R2, respectively) and thus the T1- and T2-relaxivities of these chelates. These T1- and T2-relaxivities, together with their pharmacokinetic properties (i.e. distribution and concentration in the area of interest), determine the radiologic efficacy of the gadolinium-based contrast agents.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781607 | PMC |
| http://dx.doi.org/10.1102/1470-7330.2013.9018 | DOI Listing |
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