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Could polymerase chain reaction tests on conjunctival swabs be useful to diagnose herpetic keratitis? | LitMetric
Introduction : Diagnosis of HSV-1 keratitis (HK) is frequently based on clinical findings. Invasive specimens (corneal scrapings, biopsies) are required for microbiological diagnosis.Methods : Corneal scrapings and conjunctival swabs were collected on patients with/without clinical suspicion of HK from 2007 to 2012.Results : The sensitivity, specificity, positive and negative predictive values for conjunctival swabs by PCR was 77.8, 92.1, 84.4 and 88.3, respectively.Discussion : Conjunctival swabs by PCR may help in the diagnosis of HK, despite the limited sensitivity.
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