AI Article Synopsis
- The study aimed to explore the link between the SNP rs12740374 and acute ischemic stroke in a Chinese Han population, involving 778 stroke patients and 602 controls.
- Researchers used genotyping techniques to compare genetic variations between the two groups and also looked at the connection of rs12740374 with low-density lipoprotein cholesterol (LDL-C) levels.
- The findings indicated that while all genotypes of rs12740374 were present in both groups, there was no significant association between this SNP and ischemic stroke or LDL-C levels after accounting for other risk factors.
Article Abstract
Objective: To investigate the association between single nucleotide polymorphism (SNP) rs12740374 and acute ischemic stroke in Chinese Han population.
Methods: All subjects (778 ischemic stroke patients and 602 controls) were genotyped using ligation detection reaction (LDR). We analyzed the differences among all genotypes in two groups, as well as the association between rs12740374 and low-density lipoprotein cholesterol (LDL-C).
Results: All three genotypes (GG, GT, TT) of rs12740374 were found in both stroke and control group. After adjusting for risk factors, although there was a trend that participants with a minor allele T of rs12740374 (GT/TT) had lower LDL-C concentration, no significant association was found between rs12740374 and ischemic stroke, and also no significant association between different genotypes and LDL-C was found.
Conclusion: SNPs of rs12740374 was not significantly associated with ischemic stroke in the Chinese Han population.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!