Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670300 | PMC |
| http://dx.doi.org/10.4161/jkst.20939 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cardiac fibroblast-specific expression of IL-37 confers the protective effects on fibrosis in diabetic cardiomyopathy mice by regulating SOCS3-STAT3 axis.
J Geriatr Cardiol
November 2024
Department of Cardiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Human interleukin (IL)-37 is a constituent of the IL-1 family with potent anti-inflammatory and immunosuppressive attributes. It has been demonstrated extensive beneficial effects on various diseases; however, its role in the pathogenesis of diabetic cardiomyopathy (DCM) remains unclear.
Methods: , DCM mouse model was established with streptozotocin injection and a high-fat diet in WT and cardiac fibroblasts (CFs) specific hIL-37b overexpression mice (IL-37-Tg).
Analyzing immune cell infiltrates in skeletal muscle of infantile-onset Pompe disease using bioinformatics and machine learning.
Sci Rep
November 2024
Department of Medical Genetics, West China Hospital, Sichuan University, No.37, Guoxue Lane, Wuhou District, Chengdu, China.
Article Synopsis
- - Pompe disease is a serious genetic disorder that leads to heart issues, muscle weakness, and breathing problems; this study seeks to find new markers related to the infantile form of the disease by studying gene expression and immune cell presence in affected muscles.
- - Researchers analyzed gene expression data from two datasets and used machine learning techniques like SVM-RFE and LASSO to identify potential biomarkers, discovering key genes GPNMB, CALML6, and TRIM7 that correlate with immune cells involved in the disease.
- - While the study identified important connections between these genes and immune cell activity, previous research has indicated a lack of substantial immune cell presence in muscle biopsies from Pompe patients, suggesting a need for more laboratory experiments to confirm these
Mechanistic role of mesencephalic astrocyte-derived neurotrophic factor in myocardial ischemia/reperfusion injury.
Mol Med
October 2024
Department of Medicine, Division of Cardiology, Wilf Family Cardiovascular Research Institute, Einstein Institute for Neuroimmunology and Inflammation (INI), Albert Einstein College of Medicine, Montefiore University Hospital, 1300 Morris Park Avenue, New York, NY, 10461, USA.
Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a protein crucial for cellular stress response and survival, particularly in the nervous and cardiovascular systems. Unlike traditional neurotrophic factors, MANF primarily regulates endoplasmic reticulum (ER) stress and protects cells by reducing ER stress-induced apoptosis. MANF operates both inside and outside cells, influencing key pathways like JAK/STAT and NF-κB to enhance cell survival during stress.
View Article and Find Full Text PDFMethamphetamine-induced cardiotoxicity: in search of protective transcriptional mechanisms.
Herz
December 2024
Department of Psychosomatic Medicine and Psychotherapy, University of Göttingen, Waldweg 33, 37073, Göttingen, Germany.
Crystalline methamphetamine hydrochloride is an illegal drug with a high addictive potential, better known by its colloquial name "ice" or "crystal meth". The abuse of this drug has led to significant health problems worldwide. Like other amphetamine-type stimulants, chronic consumption of methamphetamine leads to direct toxic effects on the central nervous system, causing cognitive impairment, depressive behavior, and other severe neurological or psychiatric symptoms.
View Article and Find Full Text PDFInterleukin 11 therapy causes acute left ventricular dysfunction.
Cardiovasc Res
December 2024
MRC-Laboratory of Medical Sciences, Hammersmith Hospital Campus, London W12 0NN, UK.
Article Synopsis
- Interleukin 11 (IL11) was initially developed as a treatment for low platelet levels but has shown serious cardiac side effects, prompting researchers to investigate its toxic effects on heart cells for the first time.
- The study involved injecting recombinant IL11 into mice and using various scientific techniques to assess its effects on heart function and gene expression, revealing drastic reductions in heart performance and increased activation of inflammatory pathways.
- Findings from cardiomyocyte-specific knockout mouse models showed that IL11 directly induces stress responses and gene expression changes in heart cells, further solidifying its role in heart toxicity rather than protection.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!