AI Article Synopsis

  • The activity of transcription factors is crucial for determining cell fates, specifically in hematopoietic stem cells, impacting their ability to either self-renew or differentiate.
  • A delicate balance must be maintained between self-renewal and differentiation to prevent the depletion of stem cells or the risk of developing leukemia.
  • This review will focus on the role of the transcription factor STAT5 in normal and leukemic hematopoietic stem cells, exploring how its dysregulation may lead to leukemia development.

Article Abstract

The level of transcription factor activity critically regulates cell fate decisions such as hematopoietic stem cell self-renewal and differentiation. The balance between hematopoietic stem cell self-renewal and differentiation needs to be tightly controlled, as a shift toward differentiation might exhaust the stem cell pool, while a shift toward self-renewal might mark the onset of leukemic transformation. A number of transcription factors have been proposed to be critically involved in governing stem cell fate and lineage commitment, such as Hox transcription factors, c-Myc, Notch1, β-catenin, C/ebpα, Pu.1 and STAT5. It is therefore no surprise that dysregulation of these transcription factors can also contribute to the development of leukemias. This review will discuss the role of STAT5 in both normal and leukemic hematopoietic stem cells as well as mechanisms by which STAT5 might contribute to the development of human leukemias.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3670129PMC
http://dx.doi.org/10.4161/jkst.19316DOI Listing

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