AI Article Synopsis
- A new technique was developed in pigs to create a 'composite bowel tube' (CBT) using grafts of ileal mucosa on a section of colonic muscle.
- Macroscopic and microscopic evaluations showed that six out of eight animals successfully developed a viable bowel loop, while two experienced graft failure.
- The absorption studies indicated that the grafted ileo-colic loop functioned similarly to the ileum, suggesting that the CBT could be a promising option for treating short-bowel syndrome by optimizing nutrient absorption.
Article Abstract
A reproducible technique was developed experimentally in pigs for construction of a 'composite bowel tube' (CBT) made up of ileal mucosa that was grafted to a mucosally denuded colonic muscle surface vascularised by the colonic mesentery. Macroscopic and microscopic studies at terminal laparotomy revealed a viable, mucosally lined, patent peristaltic loop of bowel in six of the eight animals. Two animals died after sloughing the grafted mucosa. In vivo absorption studies, using l-alanine as an index of amino acid absorption, showed a transport pattern through the grafted mucosa of the composite ileo-colic loop appropriate to ileum when compared with controls. The CBT constitutes another autologous gastro-intestinal reconstructive technique for redistribution of available absorptive mucosa over a longer intestinal length, and may therefore be of benefit in the management of the short-bowel syndrome.
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| http://dx.doi.org/10.1007/BF00178430 | DOI Listing |
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