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Revealing the heterogeneity of treatment resistance in less-defined subtype diffuse large B cell lymphoma patients by integrating programmed cell death patterns and liquid biopsy.
Clin Transl Med
January 2025
Department of Hematology, The First Affiliated Hospital of Nanjing Medical University, Jiangsu Province Hospital, Nanjing, China.
Precision medicine in less-defined subtype diffuse large B-cell lymphoma (DLBCL) remains a challenge due to the heterogeneous nature of the disease. Programmed cell death (PCD) pathways are crucial in the advancement of lymphoma and serve as significant prognostic markers for individuals afflicted with lymphoid cancers. To identify robust prognostic biomarkers that can guide personalized management for less-defined subtype DLBCL patients, we integrated multi-omics data derived from 339 standard R-CHOP-treated patients diagnosed with less-defined subtype DLBCL from three independent cohorts.
View Article and Find Full Text PDFInvestigating the influence of working status changes on physical activity and non-communicable diseases in Korean middle-aged and older adults: insights from a longitudinal panel study.
BMC Public Health
December 2024
Department of Physical Education, Kyung Hee University, Yongin-si, Gyeonggi-do, Korea.
Background: Non-communicable diseases (NCDs) are a major global health challenge and occupational status is a critical determinant influencing NCD development, yet many cross-sectional studies have only linked current occupational status with specific diseases, overlooking broader temporal factors. The primary aim of the present study was to comprehensively elucidate the intricate interplay between alterations in working status, NCDs, and physical activity (PA) among Korean middle-aged and older adults, employing a longitudinal panel study design.
Methods: This study utilized longitudinal data from the Korean Longitudinal Study of Aging, covering the period from 2006 to 2020, with a median follow-up duration of 10 years.
Haematological deterioration of Hematodinium-infected decapod crustaceans.
Dev Comp Immunol
December 2024
Zoology and Ryan Institute, School of Natural Sciences, University of Galway, Galway H91 TK33, Ireland. Electronic address:
Parasitic dinoflagellates, namely Hematodinium spp., infect a growing number of decapod crustacean species worldwide. These parasites represent a longstanding concern for fisheries in Europe and North America, and an emerging concern for aqua/polyculture systems in Asia.
View Article and Find Full Text PDFSensitive Aflatoxin M1 Detection in Milk by ELISA: Investigation of Different Assay Configurations.
Toxins (Basel)
November 2024
Immunoassays/Immunosensors Lab, Institute of Nuclear & Radiological Sciences & Technology, Energy & Safety, NCSR "Demokritos", 15341 Aghia Paraskevi, Greece.
Aflatoxin M1 (AFM1) exposure through dairy products is associated with adverse health effects, including hepatotoxicity and carcinogenicity. Therefore, the AFM1 presence in milk and dairy products is strictly regulated. In this context, the current work focuses on the investigation of different competitive enzyme immunoassay configurations for the determination of AFM1 in milk with high sensitivity and short assay duration.
View Article and Find Full Text PDFCalcitriol Concentration in the Early Phase of Myocardial Infarction and Its Relation to Left Ventricular Ejection Fraction.
Metabolites
December 2024
Department of Cardiology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, Poland.
Vitamin D deficiency is one of the most common metabolic disorders in the European population. A low level of 25-OH vitamin D3 is related to an elevated risk of myocardial infarction (MI). The aim of our study was to examine the relationship between calcidiol and calcitriol serum concentration and left ventricular ejection fraction early after interventional treatment for acute coronary syndrome.
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