Previous studies have confirmed the therapeutic effects of bone marrow stromal cells (BMSCs) transplantation on cerebral ischemia. However, the proliferative, differentiative, and homing capacity of BMSC from the elderly are significantly reduced, especially after several passages expansion in vitro. In this study, by introducing lentivirus-mediated hTERT and VEGF genes to modify human BMSCs from aged donors, we observed extended lifespan, promoted angiogenic capacity while less enhanced tumorigenicity of the genetically engineering BMSCs. These results therefore suggest that the modification of aged BMSCs by dual expression of hTERT and VEGF may be used for autologous cell replacement for ischemic cerebrovascular disease in elderly patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bbrc.2013.09.053 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Imaging tumor and ascites-associated macrophages in a mouse model of metastatic ovarian cancer.
EJNMMI Res
November 2024
Department of Radiology and Radiological Science, The Russell H. Morgan, Johns Hopkins School of Medicine, Baltimore, MD, USA.
Article Synopsis
- Tumor-Associated Macrophages (TAMs) are crucial in the development and progression of ovarian cancer, and a PET radiotracer called [I]iodo-DPA-713 is being used to image these macrophages in various tumor contexts.
- The study utilized PET/MRI imaging to visualize TAM activity in primary and metastatic tumors in a mouse model, showing significant radiotracer uptake in the vicinity of the tumors and in areas affected by ascites.
- Results indicated a strong correlation between PET tracer uptake and the presence of TAMs surrounding tumors, with distinct uptake patterns observed in both primary and secondary tumor sites, as well as in the gastrointestinal tract of affected mice.
Human ARMC6 binds in vitro to both cancer genes and telomeric RNA, favoring G-quadruplex structure recognition.
Biochim Biophys Acta Gene Regul Mech
September 2024
Institute of Biophysics, Academy of Sciences of the Czech Republic v.v.i., Královopolská 135, 612 00 Brno, Czech Republic; Department of Molecular Pharmacy, Faculty of Pharmacy, Masaryk University, Palackého 1/3, 612 42 Brno, Czech Republic. Electronic address:
Article Synopsis
- Armadillo repeat-containing proteins (ARMCs) are important for various cellular functions like adhesion, signaling, and regulating cellular structures, with ARMC6 being significant in primates but its specific roles were previously unclear.
- Recent experiments show that ARMC6 binds to DNA promoter sequences of cancer-related genes and to telomeric RNA, suggesting involvement in chromosomal maintenance via recognition of G-quadruplex structures.
- Overexpression of ARMC6 in human cell lines leads to altered expression of oncogenic and telomerase-related genes, highlighting its potential role in linking gene regulation with telomeric chromatin rearrangement.
New benzimidazole-oxadiazole derivatives as potent VEGFR-2 inhibitors: Synthesis, anticancer evaluation, and docking study.
Drug Dev Res
June 2024
Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Anadolu University, Eskişehir, Turkey.
We report herein, the design and synthesis of benzimidazole-oxadiazole derivatives as new inhibitors for vascular endothelial growth factor receptor-2 (VEGFR-2). The designed members were assessed for their in vitro anticancer activity against three cancer cell lines and two normal cell lines; A549, MCF-7, PANC-1, hTERT-HPNE and CCD-19Lu. Compounds 4c and 4d were found to be the most effective compounds against three cancer cell lines.
View Article and Find Full Text PDFEvaluation of Some Prognostic Biomarkers in Human Papillomavirus-Related Multiphenotypic Sinonasal Carcinoma.
Iran J Med Sci
March 2024
Department of Pathology, Faculty of Medicine, Beni-Suef University, Beni-Suef Egypt.
Background: Human papillomavirus (HPV)-related multi phenotypic sinonasal carcinoma (HMSC) is a recently described tumor subtype with an unknown prognosis, often misdiagnosed with other sinonasal carcinomas, and associated with high-risk HPV (HR-HPV). The present study aimed to evaluate the expression of vascular endothelial growth factor (VEGF), Bcl-2-associated X protein (BAX), epidermal growth factor receptors (EGFR), ProExC, and human telomerase reverse transcriptase (hTERT) and assess their association with survival and clinicopathological characteristics.
Methods: Between 2017 and 2022, 40 HMSC patients underwent surgical resection at the School of Medicine, Zagazig University Hospitals (Zagazig, Egypt).
Alterations in p53 Influence hTERT, VEGF and MMPs Expression in Oral Cancer Patients.
Asian Pac J Cancer Prev
September 2022
Molecular Oncology Laboratory, Cancer Biology Department, The Gujarat Cancer & Research Institute, Asarwa, Ahmedabad -380 016, Gujarat, India.
Background: Mutant p53 is the crucial molecule in the etiopathogenesis of oral cancer. Therefore, we aimed to evaluate the impact of alterations of the p53 gene and its negative feedback regulator, MDM2, on the expression of hTERT, VEGF, and MMPs; the critical genes involved in oral cancer progression.
Material And Methods: p53 and MDM2 genotyping were done by PCR-RFLP.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!