AI Article Synopsis
- The study aimed to assess the effectiveness of cardiac troponin (cTn) and NT-proBNP as indicators of cardiotoxicity caused by the drug amitriptyline, known for its toxic cardiac effects.
- Male Wistar rats were divided into control and amitriptyline groups, and blood samples were taken 30 minutes post-administration to measure cTn and NT-proBNP levels through different methods.
- Results showed significant increases in cTnT and NT-proBNP levels in rats treated with amitriptyline, along with some histopathological signs of cardiac injury, indicating these markers could signal early cardiotoxicity, though more research is needed on irreversible heart damage.
Article Abstract
The main objective of this study was to investigate whether cardiac troponin (cTn) and N-terminal, protein B-type natriuretic peptide (NT-proBNP) can be useful as indicators for amitriptyline cardiotoxicity which is a known drug having sublethal toxic cardiac effects. At the same time, this study looked at detecting potential histopathological changes specific to irreversible cardiac injuries in a rat model of amitriptyline cardiotoxicity. Male Wistar rats were randomly divided into 2 groups, control (saline) group and amitriptyline group (100 mg/kg body weight intraperitoneally, equivalent for lethal dose at 50%). Blood was collected 30 minutes after the administration. The cTn was measured using 3 different methods (2 methods designed for human use and a sandwich enzyme immunoassay specific for rat cTnT). The brain natriuretic peptide was measured by 2 different methods (1 for human and 1 specific for rats). Electrocardiography showed that the QRS complex (P < .0001) and the QT interval (P = .002) were significantly prolonged for amitriptyline-treated animals. Troponin T and NT-proBNP had significantly increased levels in all the rats but showed positive results only when using rat-specific quantitative measurement. In certain rats, the histopathological examination identified a few small foci of acute myocardial necrosis. In conclusion, elevation of cTnT and NT-proBNP are early indicators of cardiotoxicity, yet the significance of irreversible myocardial damage in amitriptyline cardiotoxicity needs to be further understood.
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| http://dx.doi.org/10.1177/1091581813503888 | DOI Listing |
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