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Fulminant non-traumatic Clostridium perfringens necrotizing fasciitis and myonecrosis in a child with acute myeloid leukemia.
J Infect Public Health
December 2024
Department of Pediatric Infectious Diseases, Ministry of National Guard-Health Affairs (MNGHA), King Abdullah Specialist Children Hospital, Riyadh, Saudi Arabia; King Abdullah International Medical Research Centre, King Abdulaziz Medical City, Ministry of National Guard-Health Affairs, Riyadh, Saudi Arabia; Department of Pathology and Laboratory Medicine, King Abdulaziz Medical City (KAMC), MNGHA, Riyadh, Saudi Arabia.
Necrotizing fasciitis is a potentially life-threatening infection that can lead to rapid muscular and fascial necrosis, often resulting in sepsis. In addition to the rapid disease progression, diagnosing this disease in children can be challenging as they cannot accurately communicate their symptoms. Spontaneous necrotizing fasciitis secondary to Clostridial infection has rarely been described in the literature but occurs in neutropenic patients with significant morbidity and mortality from myonecrosis and gas gangrene.
View Article and Find Full Text PDFNo Muscle Left Behind: Cardiac Arrest and Myocarditis in a Patient With Idiopathic Inflammatory Myopathy.
Cureus
October 2024
Advanced Heart Failure and Cardiac Transplant Program, Methodist Heart and Lung Institute Heart Failure and Transplant Clinic, San Antonio, USA.
Article Synopsis
- Idiopathic inflammatory myopathies (IIM) can affect the heart, leading to serious conditions like myocarditis and cardiac arrest, yet specific treatment guidelines are lacking.
- A case study discusses a 71-year-old man with newly diagnosed myositis who suffered a cardiac arrest linked to his condition, following symptoms of muscle weakness and elevated enzyme levels.
- After being resuscitated, he showed signs of myocarditis but improved with treatment, including an implantable cardioverter defibrillator and intravenous immunoglobulin therapy.
Anti-melanoma differentiation-associated gene 5 (anti-MDA5) positive dermatomyositis: early detection is crucial.
BMJ Case Rep
June 2024
Department of Rheumatology, Alfred Health, Melbourne, Victoria, Australia.
Anti-melanoma differentiation-associated gene 5-positive (Anti-MDA5) dermatomyositis (DM) is an aggressive phenotype of DM associated with rapidly progressive interstitial lung disease (RP-ILD). It is a rare condition that carries high mortality. Diagnosis and management of patients with anti-MDA5 DM RP-ILD presents several challenges, including uncertainty around treatment algorithms and a lack of evidence to inform practice.
View Article and Find Full Text PDFAdult Hemophagocytic Lymphohistiocytosis Mimicking Acute Viral Hepatitis.
Dig Dis Sci
August 2023
Division of Gastroenterology and Hepatology, Center for Digestive Health, Virginia Mason Franciscan Health, 1201 Ninth Ave, Seattle, WA, 98101, USA.
Adult hemophagocytic lymphohistiocytosis is a lifethreatenning disease which has hepatic manifestations mimicking acute hepatitis or can present with fulminant hepatic failure. The undelying pathophysiology is immune dysregulation causing a hyperinflammatory state. Clues to diagnosis include extremely high ferritin levels, whereas definitive diagnosis is usually made by bone marrow, as opposed to liver biopsy.
View Article and Find Full Text PDFTrochanteric bursitis is a common disorder affecting middle-aged adults and usually presents with lateral-based hip pain and swelling. It usually responds to conservative measures, including adductor stretching, abductor strengthening, and select injections of corticosteroid or platelet-rich plasma. For refractory cases, excision, open or arthroscopic, is usually recommended.
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