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Application and development of biosensing strategies for the analysis of the activity of the tumour-associated enzyme FEN1.
Talanta
January 2025
Department of Transfusion Medicine, West China Hospital of Sichuan University, Sichuan, 610041, PR China. Electronic address:
As a core genetic biomolecule in ecosystems, the metabolic processes of DNA, particularly DNA replication and damage repair, are regulated by Flap endonuclease 1 (FEN1). Abnormal expression and dysfunction of FEN1 may lead to genomic instability, which can induce a variety of chromosome-associated disorders, including tumours. FEN1 has emerged as a prominent tumour marker.
View Article and Find Full Text PDFFraxetin attenuates DNA damage and inflammation in cisplatin-induced nephrotoxicity via FoxO1 activation.
Int Immunopharmacol
January 2025
Department of Trauma Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, China. Electronic address:
Background: Cisplatin-induced acute kidney injury (CKI) represents a severe renal dysfunction characterized by DNA damage and tubular injury. Fraxetin, derived from the Chinese herb Qinpi (Fraxinus bungeana A.DOC), is recognized for its neuroprotective effects and has been used for the prevention of various diseases.
View Article and Find Full Text PDFLong-term exposure to Emamectin benzoate impairs reproductive health in adult zebrafish and alters neurodevelopment in their offspring.
J Hazard Mater
December 2024
Key Laboratory of Pesticide Environmental Assessment and Pollution Control, Nanjing Institute of Environmental Sciences, Ministry of Ecology and Environment, Nanjing 210042, China. Electronic address:
Emamectin benzoate (EMB) is a widely used insecticide that can accumulate in aquatic environments under specific conditions of high application intensity or improper management, posing potential risks to aquatic organisms and human health. This study aimed to evaluate the reproductive toxicity of long-term EMB exposure in zebrafish (Danio rerio) and neurodevelopmental toxicity in their offspring. Zebrafish embryos were exposed to various concentrations of EMB (0, 0.
View Article and Find Full Text PDFAnalysis of cytotoxicity and genotoxicity of diesel exhaust PM2.5 generated from diesel and dual natural gas-diesel engines.
Environ Toxicol Pharmacol
January 2025
Facultad de Medicina. Grupo de Genética Médica, Universidad de Antioquia, Medellín- Colombia. Electronic address:
Diesel exhaust particles (DEPs) are atmospheric pollutants associated with adverse health effects. In response to their impact, natural gas (NG) has emerged as a promising alternative fuel due to its cleaner combustion. Although the cytotoxicity and genotoxicity of DEPs from diesel or NG engines have been extensively studied, the impact of dual natural gas-diesel systems remains unexplored.
View Article and Find Full Text PDFEffects of environmental bisphenol S exposure on male rat reproductive health and gut-blood-testicular axis integrity.
Ecotoxicol Environ Saf
January 2025
School of Basic Medical Sciences, Hubei University of Chinese Medicine, Wuhan 430065, China; Hubei Shizhen Laboratory, Wuhan 430061, China. Electronic address:
In this study, male Sprague-Dawley (SD) rats were exposed to bisphenol S (BPS) at environmentally relevant concentrations to investigate its reproductive toxicity and evaluate its effects on the gut-blood-testicular axis. After 28 days of exposure to BPS (0.05 and 20 mg/kg), the results showed a reduction in weight gain and the induction of reproductive toxicity in male rats, including decreased sperm parameters, lower sperm viability, and increased abnormal sperm density and mortality.
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