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N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions. | LitMetric
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N-tert-Butoxycarbonylation of Structurally Diverse Amines and Sulfamides under Water-Mediated Catalyst-Free Conditions.

Zinelaabine Cheraiet Souad Ouarna Sihem Hessainia Malika Berredjem Nour-Eddine Aouf

ISRN Org Chem

LCOA, Bioorganic Chemistry Group, Chemistry Department, Sciences Faculty, Badji Mokhtar-Annaba University, P.O. Box. 12, 23000 Annaba, Algeria.

Published: September 2013

A simple, efficient, and eco-friendly protocol for the N-Boc protection of the amine moiety in a variety of compounds with di-tert-butyl dicarbonate under water-acetone catalyst-free conditions is described. The corresponding monocarbamate is obtained in excellent yields on short reaction times. No competitive side reactions such as isocyanate urea and O-Boc were observed. This method represents a reasonable alternative to the previous reported protection procedures.

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 Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3767329PMC
http://dx.doi.org/10.5402/2012/404235DOI Listing

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