AI Article Synopsis
- - The study highlights the importance of glycosylation in proteoglycans for proper animal development, indicating that balance in sugar chains is essential.
- - Researchers found that the microRNA mir-79 in *Caenorhabditis elegans* regulates this glycosylation process by targeting two key proteins involved in proteoglycan biosynthesis.
- - A loss of mir-79 leads to neurodevelopmental issues due to disruptions in a biosynthetic pathway, affecting heparan sulfate production and ultimately hindering neuronal migration.
Article Abstract
An appropriate balance in glycosylation of proteoglycans is crucial for their ability to regulate animal development. Here, we report that the Caenorhabditis elegans microRNA mir-79, an ortholog of mammalian miR-9, controls sugar-chain homeostasis by targeting two proteins in the proteoglycan biosynthetic pathway: a chondroitin synthase (SQV-5; squashed vulva-5) and a uridine 5'-diphosphate-sugar transporter (SQV-7). Loss of mir-79 causes neurodevelopmental defects through SQV-5 and SQV-7 dysregulation in the epidermis. This results in a partial shutdown of heparan sulfate biosynthesis that impinges on a LON-2/glypican pathway and disrupts neuronal migration. Our results identify a regulatory axis controlled by a conserved microRNA that maintains proteoglycan homeostasis in cells.
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| http://dx.doi.org/10.1126/science.1242528 | DOI Listing |
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