Electronic Health Records (EHRs) have emerged as a cost-effective data source for conducting medical research. The difficulty in using EHRs for research purposes, however, is that both patient selection and record analysis must be conducted across very large, and typically very noisy datasets. Our previous work introduced EventFlow, a visualization tool that transforms an entire dataset of temporal event records into an aggregated display, allowing researchers to analyze population-level patterns and trends. As datasets become larger and more varied, however, it becomes increasingly difficult to provide a succinct, summarizing display. This paper presents a series of user-driven data simplifications that allow researchers to pare event records down to their core elements. Furthermore, we present a novel metric for measuring visual complexity, and a language for codifying disjoint strategies into an overarching simplification framework. These simplifications were used by real-world researchers to gain new and valuable insights from initially overwhelming datasets.
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http://dx.doi.org/10.1109/TVCG.2013.200 | DOI Listing |
Human endocrine cell differentiation and islet morphogenesis play critical roles in determining islet cell mass and function, but the events and timeline of these processes are incompletely defined. To better understand early human islet cell development and maturation, we collected 115 pediatric pancreata and mapped morphological and spatiotemporal changes from birth through the first ten years of life. Using quantitative analyses and a combination of complementary tissue imaging approaches, including confocal microscopy and whole-slide imaging, we developed an integrated model for endocrine cell formation and islet architecture, including endocrine cell type heterogeneity and abundance, endocrine cell proliferation, and islet vascularization and innervation.
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January 2025
Department of Psychology, Tufts University, Medford, MA, USA.
Individuals are often exposed to information regarding previously witnessed events. The misinformation effect occurs when inaccurate post-event information impairs accuracy on a subsequent test of memory for the original event. The misinformation effect is increased when a test is given prior to exposure to post-event information, a phenomenon termed Retrieval Enhanced Suggestibility (RES).
View Article and Find Full Text PDFNat Commun
January 2025
Laboratory of Ion Beam Physics, ETH Zurich, Otto-Stern Weg 5 HPK, 8093, Zurich, Switzerland.
The Sun drives Earth's energy systems, influencing weather, ocean currents, and agricultural productivity. Understanding solar variability is critical, but direct observations are limited to 400 years of sunspot records. To extend this timeline, cosmic ray-produced radionuclides like C in tree-rings provide invaluable insights.
View Article and Find Full Text PDFProc Natl Acad Sci U S A
January 2025
Department of Civil and Environmental Engineering, Western University, London, ON N6A 5B9, Canada.
Induced earthquakes are manifestations of highly heterogeneous distributions of effective stress changes imparted by anthropogenic activities such as hydraulic fracturing and wastewater injection. It is critical to disentangle the mechanisms behind these earthquakes to better assess seismic risk. Here, a clustering methodology is applied to a catalog of 21,536 induced earthquakes detected during a 36-d hydraulic stimulation program in Western Canada.
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January 2025
Department of Child and Adolescent Psychiatry, New York University Grossman School of Medicine.
Individual differences in how the brain responds to novelty are present from infancy. A common method of studying novelty processing is through event-related potentials (ERPs). While ERPs possess millisecond precision, spatial resolution remains poor, especially in infancy.
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