We propose a novel approach of distance-based spatial clustering and contribute a heuristic computation of input parameters for guiding users in the search of interesting cluster constellations. We thereby combine computational geometry with interactive visualization into one coherent framework. Our approach entails displaying the results of the heuristics to users, as shown in Figure 1, providing a setting from which to start the exploration and data analysis. Addition interaction capabilities are available containing visual feedback for exploring further clustering options and is able to cope with noise in the data. We evaluate, and show the benefits of our approach on a sophisticated artificial dataset and demonstrate its usefulness on real-world data.
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http://dx.doi.org/10.1109/TVCG.2013.224 | DOI Listing |
Neuro Oncol
January 2025
Department of Neurosurgery, Universitätsklinikum Erlangen, Friedrich-Alexander-Universität Erlangen-Nürnberg.
Background: Peripheral nerve sheath tumors (PNSTs) encompass entities with different cellular differentiation and degrees of malignancy. Spatial heterogeneity complicates diagnosis and grading of PNSTs in some cases. In malignant PNST (MPNST) for example, single cell sequencing data has shown dissimilar differentiation states of tumor cells.
View Article and Find Full Text PDFAdv Sci (Weinh)
January 2025
CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Chinese Academy of Sciences, Shanghai, 200031, China.
The primate cerebral cortex, the major organ for cognition, consists of an immense number of neurons. However, the organizational principles governing these neurons remain unclear. By accessing the single-cell spatial transcriptome of over 25 million neuron cells across the entire macaque cortex, it is discovered that the distribution of neurons within cortical layers is highly non-random.
View Article and Find Full Text PDFBrain Commun
January 2025
Institute for Stroke and Dementia Research, University Hospital, Ludwig Maximilian University of Munich, Munich 81377, Germany.
Traumatic brain injury is widely viewed as a risk factor for dementia, but the biological mechanisms underlying this association are still unclear. In previous studies, traumatic brain injury has been associated with the hallmark pathologies of Alzheimer's disease, i.e.
View Article and Find Full Text PDFFront Public Health
January 2025
School of Business Administration, Zhongnan University of Economics and Law, Wuhan, China.
Background: Exploring the coordinated relationship between urban-rural integration and air quality has significant implications for promoting urban-rural development, preventing air pollution and ensuring residents' health. This study takes Yangtze River middle reaches city cluster as a case study, calculates the levels of urban-rural integration and air quality development, analyzes their coupled coordination relationship and driving factors, and explores the path of coordinated development.
Methods: This study constructs a coupling coordination degree model to analyze the relationship between the urban-rural integration development level and air quality development level.
Front Public Health
January 2025
School of Computer Science and Technology, Zhengzhou University of Light Industry, Zhengzhou, China.
The accuracy of spatial clustering detection is crucial for public health policy development and identifying etiological clues. Circular and flexibly-shaped scan statistics are widely used for disease cluster detection, but differences in results arise mainly due to parameter sensitivity and variations in the scanning window shapes. This study aims to analyze the impact of parameter settings on the results of these methods and compare their performance in disease clustering detection.
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