AI Article Synopsis
- The study analyzed the effectiveness of angiotensin receptor blockers (ARBs) versus calcium channel blockers (CCBs) in reducing insulin resistance in non-diabetic patients, measured by the HOMA-IR index.
- Five clinical trials were included in the meta-analysis, revealing that ARBs significantly lowered both the HOMA-IR index and fasting plasma insulin levels compared to CCBs.
- The findings suggest that while both drug types have similar effects on blood pressure, ARBs may be the better option for non-diabetic hypertension patients due to their superior impact on insulin resistance.
Article Abstract
Objective: This study compared the efficacy of angiotensin receptor blockers (ARBs) and calcium channel blockers (CCBs) in the effect of insulin resistance (IR) as assessed using the homeostasis model assessment of insulin resistance (HOMA-IR) in non-diabetic patients.
Methods: The MEDLINE, EMBASE, and Cochrane Library databases were searched to identify studies published before December 2012 that investigated the use of ARBs and CCBs to determine the effect on the HOMA-IR index in non-diabetics. Parameters on IR and blood pressure were collected. Review Manager 5.2 and Stata 12.0 were used to perform the meta-analysis. Fixed and random effects models were applied to various aspects of the meta-analysis, which assessed the therapeutic effects of the two types of drug using the HOMA-IR index in non-diabetic patients.
Results: The meta-analysis included five clinical trials. Patient comparisons before and after treatment with ARBs and CCBs revealed that ARBs reduced the HOMA-IR index (weighted mean difference (WMD) -0.65, 95% confidence interval (CI) -0.93 to -0.38) and fasting plasma insulin (FPI) (WMD -2.01, 95% CI -3.27 to -0.74) significantly more than CCBs. No significant differences in the therapeutic effects of these two types of drug on blood pressure were observed.
Conclusion: Given that there are no significant differences in the therapeutic effects of ARBs and CCBs on blood pressure, as ARBs are superior to CCBs in their effect on the HOMA-IR index in non-diabetics, they might be a better choice in hypertension patients without diabetes.
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| http://dx.doi.org/10.1016/j.metabol.2013.08.008 | DOI Listing |
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