Multicellular aggregation of maltol-modified cells triggered by Fe(3+) ions.

Chem Commun (Camb)

Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Claverton Down, Bath, BA2 7AY, UK.

Published: October 2013

The synthesis of a maltol-derived hydrazide is described which, once attached to a cell surface, induces rapid multicellular aggregation selectively in the presence of Fe(3+) ions. Heterocellular aggregates are also reported.

Download full-text PDF

Source
http://dx.doi.org/10.1039/c3cc43727bDOI Listing

Publication Analysis

Top Keywords

multicellular aggregation
8
fe3+ ions
8
aggregation maltol-modified
4
maltol-modified cells
4
cells triggered
4
triggered fe3+
4
ions synthesis
4
synthesis maltol-derived
4
maltol-derived hydrazide
4
hydrazide described
4

Similar Publications

Three-dimensional multicellular aggregates (MCAs) like organoids and spheroids have become essential tools to study the biological mechanisms involved in the progression of diseases. In cancer research, they are now widely used as in vitro models for drug testing. However, their analysis still relies on tedious manual procedures, which hinders their routine use in large-scale biological assays.

View Article and Find Full Text PDF

Optogenetic control of cAMP oscillations reveals frequency-selective transcription factor dynamics in Dictyostelium.

Development

January 2025

Department of Biology, Faculty of Science, Toho University, 2-2-1 Miyama, Funabashi, Chiba, 274-8510, Japan.

Oscillatory dynamics and their modulation are crucial for cellular decision-making; however, analysing these dynamics remains challenging. Here, we present a tool that combines the light-activated adenylate cyclase mPAC with the cAMP biosensor Pink Flamindo, enabling precise manipulation and real-time monitoring of cAMP oscillation frequencies in Dictyostelium. High-frequency modulation of cAMP oscillations induced cell aggregation and multicellular formation, even at low cell densities, such as a few dozen cells.

View Article and Find Full Text PDF

Translationally controlled tumor protein (TCTP) is a well conserved and ubiquitously expressed multifunctional protein found in many organisms and is involved in many pathophysiological processes like cell proliferation, differentiation, development and cell death. The role of TCTP in anti-apoptosis and cancer metastasis makes it a promising candidate for cancer therapy. Dictyostelium discoideum, a protist, has two isoforms (TCTP1 and TCTP2, now referred to as TPT1 and TPT2) of which we have earlier elucidated TPT1.

View Article and Find Full Text PDF
Article Synopsis
  • Osteoarthritis (OA) is a prevalent joint disorder that leads to cartilage breakdown, causing significant pain and potential deformities, with current treatment options showing limitations.
  • Cartilage organoids, which mimic natural cartilage structures, can help advance OA research and serve as effective fillers for cartilage repair due to their three-dimensional properties and structure.
  • Silk fibroin (SF)-based hydrogels are highlighted as ideal materials for creating these organoids, providing excellent mechanical properties and biocompatibility, and their development is enhanced through artificial intelligence for optimized treatment solutions.
View Article and Find Full Text PDF

Impact of photobiomodulation on neural embryoid body formation from immortalized adipose-derived stem cells.

Stem Cell Res Ther

December 2024

Laser Research Centre, Faculty of Health Sciences, University of Johannesburg, P.O. Box 17011, Doornfontein, 2028, South Africa.

Article Synopsis
  • Embryoid bodies (EBs) are 3D aggregates from stem cells that mimic early embryonic development and are crucial for generating various stem cell types, including neural cells.
  • Photobiomodulation (PBM), a low-powered light therapy, may enhance the differentiation of adipose-derived stem cells into neural embryoid bodies (NEBs) in a 3D culture environment, addressing current methodologies' limitations.
  • Results indicate PBM at 825 nm with a fluence of 10 J/cm significantly improved NEB size, cell viability, and specific stem cell markers, suggesting increased neural precursor populations and minimal cell damage.
View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!