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Unlabelled: The prevalence of late-onset hipogonadism (LOH) in men is not accurately determined and may be overestimated. Androgen deficiency is causally linked to insulin resistance, regardless of age. Clinical signs of androgen deficiency are not uniquely specific for LOH.

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The progressive aging of the population and the wish to keep a good quality of life in advanced ages makes testosterone deficit syndrome associated with aging a health issue of increasing relevance. It is a proved fact there is a decrease of androgen levels associated with aging. Nevertheless, there are some difficulties to establish what is the actual prevalence, since there are some ambiguities about which clinical and biochemical parameters allow us to state a correct clinical diagnosis.

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[Pathogenesis, evaluation and treatment of hypogonadism in men].

Endokrynol Pol

September 2009

Klinika Endokrynologii Centrum Medycznego Kształcenia Podyplomowego, Warszawa.

Hypogonadism in men is defined as a complex of signs and symptoms due to testosterone deficiency or inappropriate production, which occurs in about 1-2%. Symptoms of hypogonadism depend primarily on the age of the male patients at the time of development of the hypogonadism (pre- or postpubertal). The dominant findings are: impaired puberty, decrease of virilization, infertility or decrease of spermatogenesis, impotence and gynecomastia.

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