In the title compound, C18H13N3O2·H2O, the oxa-diazole ring forms dihedral angles 7.21 (10) and 21.25 (11)° with the quinoline and benzene rings, respectively. The crystal structure features O-H⋯N hydrogen bonds and is further consolidated by C-H⋯O hydrogen-bonding inter-actions involving the water molecule of hydration.
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http://dx.doi.org/10.1107/S1600536813014529 | DOI Listing |
MD 805 ((2R, 4R) 4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetra-hydro-8-quinoline-sulfonyl)L- arginyl]-2-piperidine carboxylic acid monohydrate), an anticoagulant, was used in patients with chronic renal failure undergoing maintenance hemodialysis, and the results were compared with those of heparin. MD 805 produced no significant increase in PF-4 which was observed on hemodialysis with heparin. Moreover, the arterio-venous difference in beta-TG during hemodialysis with MD 805 was significantly lower than that during hemodialysis with heparin.
View Article and Find Full Text PDF(2R, 4R)4-methyl-1-[N alpha-(3-methyl-1,2,3,4-tetrahydro-8-quinoline- sulfonyl)-L-arginyl]-2-piperidine carboxylic acid monohydrate (MCI-9038) was found to be a potent synthetic inhibitor of thrombin. In concentrations as low as 1 microM, the thrombin time, prothrombin time, and partial thromboplastin time were more than doubled. The venom (Bothrops atrox) time was similarly prolonged.
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