Three new lignans (1, 2, and 8) and ten known ones (3-7, 9-13) were isolated from the roots of Vladimiria muliensis. Their structures and configurations were elucidated by means of spectroscopic techniques (IR, MS, NMR, and CD) and chemical methods. The isolated compounds were evaluated for their antioxidant and antibacterial activities. The antioxidant activity was the greatest for lignans 7 and 10 with IC50 values of 11.2 and 7.3 µM against DPPH radical, and of 1.6 and 1.7 µM against ABTS+ radical, respectively. Moreover, 7 also displayed broad-spectrum antibacterial activity with MIC values around 7.25 µg/mL.
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Selection and evaluation of quality markers (Q-markers) of vladimiriae radix extract for cholestatic liver injury based on spectrum-effect relationship, pharmacokinetics, and molecular docking.
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Holistic Integrative Medicine Industry Collaborative Innovation Research Center, Qiang Medicine Standard Research Promotion Base and Collaborative Innovation Research Center, School of Preclinical Medicine, Chengdu University, Chengdu, 610106, China. Electronic address:
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Vlasouliodes A-D, four new C dimeric sesquiterpenes exhibiting potential inhibition of MCF-7 cells from Vladimiria souliei.
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School of Traditional Chinese Pharmacy, China Pharmaceutical University, Nanjing, Jiangsu 211198, PR China; School of Pharmacy, Second Military Medical University, Shanghai 200433, PR China. Electronic address:
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View Article and Find Full Text PDFA comprehensive chemical and pharmacological review of three confusable Chinese herbal medicine-Aucklandiae radix, Vladimiriae radix, and Inulae radix.
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Biology Institute, Qilu University of Technology (Shandong Academy of Sciences), Jinan, China.
Aucklandiae radix (AR, Muxiang), vladimiriae radix (VR, Chuanmuxiang), and inulae radix (IR, Tumuxiang) are widely used in clinical or folk medicine in China. Their Chinese names all have the Chinese character "Muxiang," which makes it confusable in usage, especially AR and VR, because VR was used as a substitute for AR during a historical period. The National Health Commission of the People's Republic of China has approved AR as a functional food.
View Article and Find Full Text PDFAucklandiae Radix and Vladimiriae Radix: A systematic review in ethnopharmacology, phytochemistry and pharmacology.
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Ethnopharmacological Relevance: Aucklandiae Radix (AR) and Vladimiriae Radix (VR), as commonly used traditional Chinese herbal medicine, were widely used in the treatment of gastrointestinal diseases. The two herbal medicines were warm, pungent and bitter. They entered the spleen, stomach, large intestine and gallbladder meridians, and had the effect of promoting qi circulation to relieve pain.
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Key Laboratory of Standardization of Chinese Herbal Medicine, Ministry of Education, State Key Laboratory of Characteristic Chinese Medicine Resources in Southwest China, Chengdu University of Traditional Chinese Medicine, Chengdu, 611137, China. Electronic address:
Background: The intestinal flora imbalance and metabolic disorders are closely related to the pathogenesis of ulcerative colitis (UC). As a commonly used herb for the treatment of gastrointestinal diseases, Vladimiriae Radix (VR) has been used for hundreds of years, and its main active ingredients are costunolide (COS) and dehydrocostus lactone (DEH). Clinical usage habits and previous studies have shown that the processed Vladimiriae Radix (pVR) seems to be more suitable for treating bowel disease than the raw Vladimiriae Radix (rVR), but there is still no relevant comparative study.
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