AI Article Synopsis
- Recent interest in developmental programming has primarily focused on cardiovascular health and metabolic disorders, but it's been discovered that reproductive function is also affected.
- Research in various animal models like rats, sheep, and nonhuman primates shows that challenges during vital developmental stages can alter reproductive capacity.
- This review aims to explore the evidence of how reproductive function is influenced at different life stages, including fetal development, early life, puberty, active reproductive years, and aging.
Article Abstract
The recent growth of interest in developmental programming of physiological systems has generally focused on the cardiovascular system (especially hypertension) and predisposition to metabolic dysfunction (mainly obesity and diabetes). However, it is now clear that the full range of altered offspring phenotypes includes impaired reproductive function. In rats, sheep and nonhuman primates, reproductive capacity is altered by challenges experienced during critical periods of development. This review will examine available experimental evidence across commonly studied experimental species for developmental programming of female and male reproductive function throughout an individual's life-course. It is necessary to consider events that occur during fetal development, early neonatal life and prior to and during puberty, during active reproductive life and aging as reproductive performance declines.
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| http://dx.doi.org/10.1016/j.mce.2013.09.008 | DOI Listing |
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