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Advancements in drug discovery: integrating CADD tools and drug repurposing for PD-1/PD-L1 axis inhibition.
RSC Adv
January 2025
LAQV and REQUIMTE, Departamento de Química, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa Caparica Portugal
Despite significant strides in improving cancer survival rates, the global cancer burden remains substantial, with an anticipated rise in new cases. Immune checkpoints, key regulators of immune responses, play a crucial role in cancer evasion mechanisms. The discovery of immune checkpoint inhibitors (ICIs) targeting PD-1/PD-L1 has revolutionized cancer treatment, with monoclonal antibodies (mAbs) becoming widely prescribed.
View Article and Find Full Text PDFIntegration of Three-Dimensional Scanning and Computer-Aided Design/Computer-Aided Manufacturing (CAD/CAM) Technology in Routine Prosthodontic Practice: A Cross-Sectional Study in Kerala.
Cureus
December 2024
Prosthodontics, Government Dental College, Kozhikode, IND.
Background: Digital dentistry has transformed all aspects of dentistry, especially prosthodontics, and is increasingly used for diagnosis, treatment planning, execution, student training, and research. This study aimed to assess the perception, attitude, and practice of digital technology in prosthodontics among dental professionals in Kerala, India.
Materials And Methods: A cross-sectional, questionnaire-based study was conducted among dental professionals in Kerala.
Accuracy of full arch scans performed with nine different scanning patterns- an in vitro study.
Clin Oral Investig
January 2025
Department of Prosthetic Dentistry, LMU University Hospital, LMU Munich, Goethestrasse 70, 80336, Munich, Germany.
Objective: Evaluation of the accuracy of direct digitization of maxillary scans depending on the scanning strategy.
Materials And Methods: A maxillary model with a metal bar as a reference structure fixed between the second molars was digitized using the CEREC Primescan AC scanner (N = 225 scans). Nine scanning strategies were selected (n = 25 scans per strategy), differing in scan area segmentation (F = full jaw, H = half jaw, S = sextant) and scan movement pattern (L = linear, Z = zig-zag, C = combined).
Development of a Clinically Applicable Deep Learning System Based on Sparse Training Data to Accurately Detect Acute Intracranial Hemorrhage from Non-enhanced Head Computed Tomography.
Neurol Med Chir (Tokyo)
January 2025
College of Biological Science and Technology, National Yang Ming Chiao Tung University.
Non-enhanced head computed tomography is widely used for patients presenting with head trauma or stroke, given acute intracranial hemorrhage significantly influences clinical decision-making. This study aimed to develop a deep learning algorithm, referred to as DeepCT, to detect acute intracranial hemorrhage on non-enhanced head computed tomography images and evaluate its clinical applicability. We retrospectively collected 1,815 computed tomography image sets from a single center for model training.
View Article and Find Full Text PDFDeveloping a highly efficient 4-hydroxyphenylacetate-3-hydroxylase for salvianic acid A synthesis by computer-aided molecular modification.
Int J Biol Macromol
January 2025
Department of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China; School of Biological and Chemical Engineering, NingboTech University, Ningbo 315100, China; Jinhua Advanced Research Institute, Jinhua 321019, China. Electronic address:
Salvianic acid A (SAA) is a catechol compound known for its diverse physiochemical functions and has significant applications in the food and pharmaceutical industries. 4-Hydroxyphenylacetate-3-hydroxylase (4HPA3H) is a critical enzyme for SAA biosynthesis, and improving its activity towards p-hydroxyphenyllactate acid (4HPLA) is essential for highly efficient SAA production in stable biosynthetic pathways. To address this, the distal site and loops of the substrate pocket were modified to improve 4HPA3H catalytic activity towards 4HPLA using computer-aided molecular modification methods.
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