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A co-registration method to validate optical coherence tomography in the breast surgical cavity.
Heliyon
January 2025
BRITElab, Harry Perkins Institute of Medical Research, QEII Medical Centre Nedlands and Centre for Medical Research, The University of Western Australia, Perth, Australia.
Breast-conserving surgery accompanied by adjuvant radiotherapy is the standard of care for patients with early-stage breast cancer. However, re-excision is reported in 20-30 % of cases, largely because of close or involved tumor margins in the specimen. Several intraoperative tumor margin assessment techniques have been proposed to overcome this issue, however, none have been widely adopted.
View Article and Find Full Text PDFMolecular dynamics model of mechanophore sensors for biological force measurement.
Heliyon
January 2025
School of Molecular Sciences, Arizona State University, Tempe, AZ, 85287, USA.
Cellular forces regulate an untold spectrum of living processes, such as cell migration, gene expression, and ion conduction. However, a quantitative description of mechanical control remains elusive due to the lack of general, live-cell tools to measure discrete forces between biomolecules. Here we introduce a computational pipeline for force measurement that leverages well-defined, tunable release of a mechanically activated small molecule fluorophore.
View Article and Find Full Text PDFEvaluating cardiac performance in beagle dogs: Transesophageal echocardiography and myocardial work assessment.
Heliyon
January 2025
Department of Ultrasound Medicine, Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, 210008, People's Republic of China.
Objectives: This study aimed to establish standard transesophageal echocardiographic (TEE) measurements of left ventricular (LV) morphology, function, and myocardial work parameters in healthy Beagle dogs using pressure-strain loops (PSL). Additionally, it sought to standardize optimal TEE imaging techniques and explore the potiential application of myocardial work analyis in veterinary medicine.
Methods: Thirty-seven healthy male Beagle dogs were anesthetized, intubated, and mechanically ventilated for TEE examinations.
Effect of modified investment and casting system on the recasting properties of high-gold alloy.
J Dent Sci
December 2024
School of Dentistry, College of Dental Medicine, Kaohsiung Medical University, Kaohsiung, Taiwan.
Background/purpose: High gold (Au) alloys have many advantages, such as good mechanical properties and stable chemical properties for dental restoration. The purpose of this investigation was to investigate the effect of zirconia (ZrO)-magnesia (MgO)-based investment combined with an argon arc vacuum pressure (Ar-arc VP) casting process on the recasting of high Au alloys.
Materials And Methods: The recasting Au alloys were compared between the control group of conventional SiO-based investment/horizontal centrifugal (HC) casting and the experimental group of ZrO-MgO-based investment/Ar-arc VP die casting.
Exploring the frontiers of metal additive manufacturing in orthopaedic implant development.
MethodsX
December 2024
Department of Mechanical Engineering, Mepco Schlenk Engineering College, Sivakasi 626005, Tamil Nadu, India.
This paper provides a thorough analysis of recent advancements and emerging trends in the integration of metal additive manufacturing (AM) within orthopedic implant development. With an emphasis on the use of various metals and alloys, including titanium, cobalt-chromium, and nickel-titanium, the review looks at their characteristics and how they relate to the creation of various orthopedic implants, such as spinal implants, hip and knee replacements, and cranial-facial reconstructions. The study highlights how metal additive manufacturing (AM) can revolutionize the field by enabling customized implant designs that take patient anatomical variances into account.
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