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ALC-0315 Lipid-Based mRNA LNP Induces Stronger Cellular Immune Responses Postvaccination.
Mol Pharm
January 2025
Ningbo No.2 Hospital, Ningbo, Zhejiang 315010, P. R. China.
At the end of 2019, SARS-CoV-2 emerged and rapidly spread, having a profound negative impact on human health and socioeconomic conditions. In response to this unprecedented global health crisis, significant advancements were made in the mRNA vaccine technology. In this study, we have compared the difference between two SARS-CoV-2 receptor-binding domain (RBD) mRNA-Lipid nanoparticle (LNP) vaccines prepared from two different ionizable cationic lipids: ALC-0315 and MC3.
View Article and Find Full Text PDFGynura procumbensin vitro adventitious root nanohydrogel improves inflammation-proliferation transition in second-degree burn healing.
Braz J Biol
January 2025
Universitas Airlangga, Faculty of Science and Technology, Department of Biology, Mulyorejo, Surabaya, Indonesia.
Inflammation-proliferation transition plays a key role in the successful healing of a common burn type, second-degree burn. Gynura procumbens in vitro adventitious root nanohydrogel is currently being studied for its immunomodulatory to improve reparative environment. Root production and nanohydrogel preparation was done respectively by in vitro propagation and emulsion/ solvent diffusion with carbomer as a polymer.
View Article and Find Full Text PDFTwo Decades Since the Unequal Treatment Report: The State of Racial, Ethnic, and Socioeconomic Disparities in Elective Total Hip and Knee Replacement Use.
J Bone Joint Surg Am
November 2024
Sidney Kimmel Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania.
Published in 2003 by the Institute of Medicine, Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care placed an unprecedented spotlight on disparities in the U.S. health-care system.
View Article and Find Full Text PDFEffects of instructional therapeutic play in the behavior of children during the first attempt at intravenous catheterization.
Rev Gaucha Enferm
January 2025
Universidade Estadual de Feira de Santana, Programa de Pós-Graduação em Ciências Farmacêuticas, Feira de Santana, Bahia, Brasil.
Objective: To verify the effects of instructional therapeutic play on the behavior of children during the first attempt at peripheral intravenous catheterization.
Method: This is a quasi-experimental post hoc analysis with a non-equivalent control group, secondary to a randomized clinical trial. The convenience sample comprised 193 children, allocated for convenience into an intervention group (preparation for catheterization with a therapeutic play; n=101 children) and a control group (preparation with structured conversation supported by the use of a booklet; n=92 children).
Morbidity and factors associated with frailty in post-COVID-19 elderly patients attended at a reference center.
Rev Bras Enferm
January 2025
Universidade Estadual de Montes Claros. Montes Claros, Minas Gerais, Brazil.
Objective: To assess the morbidity profile and identify factors associated with frailty syndrome in post-COVID-19 elderly patients treated at the only Reference Center for Elderly Health Care in northern Minas Gerais.
Methods: This is a case series study, utilizing the Clinical-Functional Vulnerability Index-20 (CFVI-20) and Comprehensive Geriatric Assessment (CGA) to characterize and evaluate the health condition of the group. To define the variables associated with frailty, a multivariate analysis was conducted.
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