A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.
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Tunable Luminescent Properties of Tricyanoosmium Nitrido Complexes Bearing a Chelating O^N Ligand.
Inorg Chem
April 2020
Department of Chemistry, City University of Hong Kong, Tat Chee Avenue, Kowloon Tong, Hong Kong.
We have recently reported a strongly luminescent osmium(VI) nitrido complex [Os(N)(NO-L)(CN)] [HNO-L = 2-(2-hydroxy-5-nitrophenyl)benzoxazole]. The excited state of this complex readily activates the strong C-H bonds of alkanes and arenes ( , , 40). In this work, we attempted to tune the excited-state properties of this complex by introducing various substituents on the bidentate L ligand.
View Article and Find Full Text PDFSynthesis and antitumor activity of a series of osmium(VI) nitrido complexes bearing quinolinolato ligands.
Chem Commun (Camb)
November 2013
Advanced Laboratory of Environmental Research and Technology (ALERT), Joint Advanced Research Center, USTC-CityU, Suzhou, Jiangsu 215123 and and School of Life Sciences, Anhui University, Hefei, Anhui 230601, China.
A series of osmium(VI) nitrido complexes supported by quinolinolato ligands have been prepared and they exhibit promising in vitro anti-cancer activities. These results establish that Os(VI)≡N is a potentially versatile and promising platform for the design of a variety of high-valent anti-cancer drugs.
View Article and Find Full Text PDFOn the hydrolysis step in osmium catalyzed asymmetric dihydroxylations.
J Org Chem
April 2007
Department of Chemistry, University of Oulu, P.O. Box 3000, FIN-90014 Oulu, Finland.
In order to obtain information about the most important features that affect the efficiency of osmium catalyzed asymmetric dihydroxylation, a series of substituted styrenes have been studied by using a Hammett type approach as well as solvent kinetic isotope effects. A concave shaped Hammett plot with a minimum at X=H revealed a change in the mechanism going from electron-donating to electron-withdrawing substituents for both NaClO2 and K3[Fe(CN)6] asymmetric dihydroxylations. The Hammett plot together with solvent isotope effect results indicates that osmium (mono)glycolates of styrenes with electron-withdrawing substituents are hydrolyzed by a stepwise attack of the nucleophile to the electrophilic osmium-center and subsequent protonation of the alkaline intermediate.
View Article and Find Full Text PDFOsmium(VI) Nitrido and Osmium(IV) Phosphoraniminato Complexes Containing Schiff Base Ligands.
Inorg Chem
December 1999
Department of Biology and Chemistry, City University of Hong Kong, Tat Chee Avenue, Hong Kong, People's Republic of China, and Department of Chemistry, The University of Hong Kong, Pokfulam Road, Hong Kong, People's Republic of China.
A series of osmium(VI) nitrido complexes containing Schiff base ligands, [Os(VI)(N)(L)Cl] (L = salophen or salen), have been synthesized by reaction of the ligand with [NBu(n)(4)][Os(VI)(N)Cl(4)] in the presence of 2,6-dimethylpyridine. The nu(Os&tbd1;N) for the salophen complexes occur at around 1070 cm(-)(1) and are insensitive to the nature of the substituents present on the Schiff base ligand. The structures of [Os(N)(salophen)(MeOH)]ClO(4) and [Os(N)(5,5-Cl(2)salophen)(MeOH)]ClO(4) have been determined by X-ray crystallography, and the Os&tbd1;N bond distances are 1.
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