Objective: In obesity, the excessive adipose tissue increases the synthesis of inflammatory cytokines, which appear to alter the metabolism of minerals, such as zinc. However, the mechanisms involved remain unclear. This study investigated whether the concentrations of interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in plasma can to influence biochemical parameters of zinc in obese women.
Methods: Seventy-six pre-menopausal women, aged between 20 and 50 years, were divided into two groups: the case group, composed of obese women (n=37) and the control group, composed of non-obese women (n=39). Analysis of the plasmatic and erythrocytary zinc, and plasmatic cytokines were conducted by flame atomic absorption spectrophotometry and by ELISA, respectively.
Results: The plasmatic zinc and concentrations of IL-6 in plasma did not show significant differences between obese women and controls (p>0.05). The erythrocytary zinc was 36.4 ± 15.0 μg/gHb in the case group, and 45.4 ± 14.3 μg/gHb (p=0.025) in the control group. The concentrations of TNF-α in plasma were 42.0 ± 11.9 pg/mL and 19.0 ± 1.0 pg/mL in obese women and in controls, respectively (p<0.001). The plasmatic zinc had a significant negative correlation with the values of TNFα (r=-0.44, p=0.015).
Conclusion: Obese women presented lower concentrations of erythrocytary zinc than the control group. The study demonstrated a probable influence of the inflammatory process on metabolism of zinc in obese patients.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.ramb.2013.03.003 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Targeting ultra-processed foods for prevention of type 2 diabetes: state of the evidence and future directions.
Diabetologia
January 2025
Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, MA, USA.
The incidence of type 2 diabetes has risen globally, in parallel with the obesity epidemic and environments promoting a sedentary lifestyle and low-quality diet. There has been scrutiny of ultra-processed foods (UPFs) as a driver of type 2 diabetes, underscored by their increasing availability and intake worldwide, across countries of all incomes. This narrative review addresses the accumulated evidence from investigations of the trends in UPF consumption and the relationship with type 2 diabetes incidence.
View Article and Find Full Text PDFRelationship of modifiable risk factors with the incidence of thyroid cancer: a worldwide study.
BMC Res Notes
January 2025
Non-Communicable Diseases Research Center, Department of Epidemiology, School of Health, Shiraz University of Medical Sciences, Shiraz, Iran.
Background: Thyroid cancer is one of the most common cancers of the endocrine system. The incidence of this cancer has increased in many countries. Many cases of thyroid cancer do not have any symptoms.
View Article and Find Full Text PDFCardiovascular risk profiling among South Asian adults in Hong Kong: a latent class analysis.
Int J Equity Health
January 2025
JC School of Public Health and Primary Care, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Background: South Asians living in urbanized settings are facing disproportionate cardiovascular burden largely attributable to modifiable risk factors. Given the rapid surge in South Asian population in Hong Kong, this study aims to identify and distinguish clusters of cardiovascular risk profiles among community-dwelling South Asian adults.
Methods: Between June 2022 and December 2023, 1181 South Asian adults were recruited through territory-wide outreach health assessments on lifestyle, psychological distress, obesity, clinical cardiovascular conditions, and sociodemographic factors.
The effects of intermittent fasting on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with rheumatoid arthritis: a randomized controlled trial.
Sci Rep
January 2025
Department of Clinical Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, P.O. Box 14155-6117, Tehran, Iran.
Rheumatoid arthritis (RA) is a chronic inflammatory disorder affecting postmenopausal women. This study investigated the effects of intermittent fasting (IF) on antioxidant and inflammatory markers and liver enzymes in postmenopausal, overweight and obese women with RA. This 8-week randomized controlled trial included 44 postmenopausal women with RA divided into an intervention group following a 16:8 IF diet and a control group maintaining their usual diet and received recommendations for healthy eating.
View Article and Find Full Text PDFFactors associated with sarcopenia in a population of non-disabled older patients.
Rev Esp Geriatr Gerontol
January 2025
Servicio de Geriatría, Hospital Universitario Ramón y Cajal (IRYCIS), Ctra. de Colmenar Viejo, km. 9,100, 28034, Madrid C.P. 28034, Mexico.
Background And Aim: To evaluate the association between sarcopenia and metabolic syndrome.
Patients And Methods: A case-control study.
Setting: Geriatric Care Clinic of Metepec (México).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!